Single cell type - MPZL3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MPZL3
Gene descriptionⁱ Full gene name according to HGNC.	Myelin protein zero like 3
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription regulation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Suprabasal keratinocytes, Urothelial cells, T-cells, Respiratory ciliated cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (eosinophil, neutrophil, basophil, MAIT T-cell)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (CAPAN-2, HMC-1, MCF7)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Suprabasal keratinocytes, Urothelial cells, T-cells, Respiratory ciliated cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MPZL3 is part of cluster 24 Non-specific - Transcription regulation with confidenceⁱ 1
415 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CD40LG	CD40 ligand	0.7456	24
PBX4	PBX homeobox 4	0.7407	24
CCR4	C-C motif chemokine receptor 4	0.7404	24
IL7R	Interleukin 7 receptor	0.7385	24
LEPROTL1	Leptin receptor overlapping transcript like 1	0.7289	24
PDCD1	Programmed cell death 1	0.7260	24
CCR8	C-C motif chemokine receptor 8	0.7183	24
CTLA4	Cytotoxic T-lymphocyte associated protein 4	0.7088	24
CD28	CD28 molecule	0.7073	24
RCAN3	RCAN family member 3	0.7033	24
IL4	Interleukin 4	0.6975	24
TNFRSF18	TNF receptor superfamily member 18	0.6931	24
PMCH	Pro-melanin concentrating hormone	0.6908	24
FOXP3	Forkhead box P3	0.6808	24
BATF	Basic leucine zipper ATF-like transcription factor	0.6605	24

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	2.4 nTPM
Adipose tissue	3.5 nTPM
Breast	1.3 nTPM

Alveolar cells type 1	16.0 nTPM
Lung	16.0 nTPM

Alveolar cells type 2	26.9 nTPM
Lung	26.9 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	4.9 nTPM
Adipose tissue	14.6 nTPM
Stomach	8.6 nTPM
Breast	6.6 nTPM
Bone marrow	5.7 nTPM
Spleen	5.2 nTPM
Lymph node	3.5 nTPM
Liver	2.9 nTPM
Colon	1.6 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM

Dendritic cells	9.6 nTPM
Adipose tissue	19.1 nTPM
Breast	5.8 nTPM
PBMC	4.0 nTPM

Endothelial cells	4.9 nTPM
Esophagus	16.1 nTPM
Skin	15.7 nTPM
Breast	7.9 nTPM
Prostate	5.6 nTPM
Testis	4.7 nTPM
Eye	4.1 nTPM
Endometrium	3.9 nTPM
Ovary	3.2 nTPM
Skeletal muscle	2.2 nTPM
Liver	1.8 nTPM
Heart muscle	1.7 nTPM
Placenta	1.7 nTPM
Lung	0.0 nTPM
Pancreas	0.0 nTPM

Fibroblasts	1.6 nTPM
Skin	9.6 nTPM
Lung	2.2 nTPM
Prostate	1.9 nTPM
Breast	1.8 nTPM
Stomach	1.5 nTPM
Placenta	0.3 nTPM
Skeletal muscle	0.2 nTPM
Ovary	0.2 nTPM
Adipose tissue	0.1 nTPM
Heart muscle	0.0 nTPM
Esophagus	0.0 nTPM

Intestinal goblet cells	5.1 nTPM
Rectum	5.5 nTPM
Colon	5.0 nTPM
Small intestine	5.0 nTPM

Macrophages	5.5 nTPM
PBMC	13.6 nTPM
Adipose tissue	12.7 nTPM
Endometrium	7.9 nTPM
Pancreas	7.7 nTPM
Kidney	7.6 nTPM
Breast	7.0 nTPM
Lung	6.7 nTPM
Skeletal muscle	4.8 nTPM
Prostate	3.4 nTPM
Testis	2.9 nTPM
Stomach	2.9 nTPM
Ovary	2.2 nTPM
Spleen	2.1 nTPM
Bone marrow	1.2 nTPM
Esophagus	0.0 nTPM

Paneth cells	9.1 nTPM
Colon	13.2 nTPM
Small intestine	7.5 nTPM
Rectum	6.5 nTPM

Plasma cells	6.6 nTPM
Adipose tissue	18.8 nTPM
Stomach	7.1 nTPM
Bone marrow	5.0 nTPM
Spleen	2.3 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	43.8 nTPM
Bronchus	62.8 nTPM
Lung	24.8 nTPM

Smooth muscle cells	2.3 nTPM
Bronchus	13.3 nTPM
Skin	5.6 nTPM
Prostate	2.2 nTPM
Endometrium	1.6 nTPM
Breast	1.6 nTPM
Pancreas	1.1 nTPM
Heart muscle	0.2 nTPM
Skeletal muscle	0.2 nTPM
Adipose tissue	0.2 nTPM
Ovary	0.1 nTPM
Esophagus	0.0 nTPM

T-cells	44.3 nTPM
Skin	182.8 nTPM
Adipose tissue	121.3 nTPM
Esophagus	72.0 nTPM
Colon	69.4 nTPM
Stomach	40.2 nTPM
Breast	39.2 nTPM
Spleen	32.7 nTPM
Endometrium	29.4 nTPM
Lung	28.8 nTPM
Prostate	28.4 nTPM
Liver	24.0 nTPM
Lymph node	17.4 nTPM
Skeletal muscle	17.2 nTPM
Bone marrow	16.2 nTPM
Ovary	13.4 nTPM
Kidney	12.3 nTPM
PBMC	7.9 nTPM

Basal keratinocytes	35.6 nTPM
Skin	35.6 nTPM

Basal prostatic cells	21.7 nTPM
Prostate	21.7 nTPM

Basal respiratory cells	11.8 nTPM
Bronchus	11.8 nTPM

Collecting duct cells	9.2 nTPM
Kidney	9.2 nTPM

Undifferentiated cells	8.1 nTPM
Colon	9.1 nTPM
Small intestine	7.8 nTPM
Rectum	7.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC