Single cell type - ORAI2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ORAI2
Gene descriptionⁱ Full gene name according to HGNC.	ORAI calcium release-activated calcium modulator 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	B-cells - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (B-cells, Endometrial ciliated cells, Glandular and luminal cells, Plasma cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (eosinophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (Daudi, RPMI-8226)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (B-cells, Endometrial ciliated cells, Glandular and luminal cells, Plasma cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ORAI2 is part of cluster 57 B-cells - Immune response with confidenceⁱ 1
204 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MBD4	Methyl-CpG binding domain 4, DNA glycosylase	0.6563	57
CD79B	CD79b molecule	0.6440	57
HLA-DOB	Major histocompatibility complex, class II, DO beta	0.6385	57
P2RX5	Purinergic receptor P2X 5	0.6355	57
TNFRSF13B	TNF receptor superfamily member 13B	0.6065	57
IGLV8-61	Immunoglobulin lambda variable 8-61	0.6051	55
QRSL1	Glutaminyl-tRNA amidotransferase subunit QRSL1	0.6018	57
CD180	CD180 molecule	0.5915	57
FCRLA	Fc receptor like A	0.5882	57
TMEM156	Transmembrane protein 156	0.5870	57
TNFRSF13C	TNF receptor superfamily member 13C	0.5859	57
CD79A	CD79a molecule	0.5737	57
BTLA	B and T lymphocyte associated	0.5713	57
CD22	CD22 molecule	0.5706	57
CNR2	Cannabinoid receptor 2	0.5691	57

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	29.0 nTPM
Adipose tissue	33.3 nTPM
Breast	24.6 nTPM

Alveolar cells type 1	3.2 nTPM
Lung	3.2 nTPM

Alveolar cells type 2	9.6 nTPM
Lung	9.6 nTPM

Astrocytes	5.2 nTPM
Brain	5.2 nTPM

Basal keratinocytes	4.0 nTPM
Skin	4.0 nTPM

B-cells	140.4 nTPM
PBMC	276.9 nTPM
Colon	214.1 nTPM
Kidney	147.5 nTPM
Stomach	136.2 nTPM
Spleen	131.2 nTPM
Adipose tissue	126.8 nTPM
Bone marrow	101.4 nTPM
Lymph node	95.1 nTPM
Liver	92.2 nTPM
Breast	83.0 nTPM

Dendritic cells	55.4 nTPM
PBMC	99.6 nTPM
Adipose tissue	35.7 nTPM
Breast	31.0 nTPM

Endothelial cells	27.0 nTPM
Ovary	54.8 nTPM
Liver	54.1 nTPM
Endometrium	41.0 nTPM
Prostate	32.5 nTPM
Eye	29.1 nTPM
Pancreas	27.0 nTPM
Lung	24.9 nTPM
Skeletal muscle	23.1 nTPM
Breast	22.5 nTPM
Placenta	21.6 nTPM
Testis	14.2 nTPM
Esophagus	13.9 nTPM
Skin	11.2 nTPM
Heart muscle	8.4 nTPM

Fibroblasts	13.9 nTPM
Ovary	26.8 nTPM
Lung	19.0 nTPM
Prostate	16.3 nTPM
Skeletal muscle	16.3 nTPM
Placenta	15.3 nTPM
Breast	13.2 nTPM
Skin	12.5 nTPM
Adipose tissue	10.0 nTPM
Stomach	8.9 nTPM
Esophagus	8.8 nTPM
Heart muscle	5.4 nTPM

Intestinal goblet cells	2.4 nTPM
Colon	3.6 nTPM
Rectum	2.8 nTPM
Small intestine	0.8 nTPM

Macrophages	33.0 nTPM
PBMC	150.1 nTPM
Lung	39.9 nTPM
Skeletal muscle	35.2 nTPM
Stomach	35.1 nTPM
Endometrium	33.2 nTPM
Breast	29.2 nTPM
Prostate	28.7 nTPM
Adipose tissue	25.5 nTPM
Spleen	22.8 nTPM
Pancreas	20.4 nTPM
Bone marrow	20.0 nTPM
Kidney	18.1 nTPM
Testis	15.1 nTPM
Ovary	11.9 nTPM
Esophagus	9.4 nTPM

Paneth cells	0.3 nTPM
Rectum	1.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	76.3 nTPM
Stomach	120.2 nTPM
Spleen	82.9 nTPM
Bone marrow	77.4 nTPM
Esophagus	61.7 nTPM
Adipose tissue	39.4 nTPM

Respiratory ciliated cells	31.2 nTPM
Bronchus	40.6 nTPM
Lung	21.9 nTPM

Smooth muscle cells	15.2 nTPM
Pancreas	33.7 nTPM
Ovary	28.0 nTPM
Endometrium	25.8 nTPM
Skeletal muscle	18.7 nTPM
Breast	14.0 nTPM
Adipose tissue	12.0 nTPM
Esophagus	7.8 nTPM
Skin	7.7 nTPM
Prostate	6.5 nTPM
Bronchus	6.5 nTPM
Heart muscle	6.0 nTPM

Cholangiocytes	8.6 nTPM
Liver	8.6 nTPM

Collecting duct cells	16.5 nTPM
Kidney	16.5 nTPM

Cone photoreceptor cells	66.7 nTPM
Eye	66.7 nTPM

Cytotrophoblasts	1.3 nTPM
Placenta	1.3 nTPM

T-cells	28.8 nTPM
Adipose tissue	43.3 nTPM
Colon	42.7 nTPM
Endometrium	40.1 nTPM
Liver	40.0 nTPM
Skeletal muscle	36.8 nTPM
PBMC	31.1 nTPM
Skin	29.9 nTPM
Breast	29.7 nTPM
Prostate	28.4 nTPM
Stomach	28.4 nTPM
Esophagus	26.2 nTPM
Spleen	23.5 nTPM
Ovary	22.3 nTPM
Bone marrow	19.7 nTPM
Kidney	17.8 nTPM
Lung	16.7 nTPM
Lymph node	13.4 nTPM

Undifferentiated cells	2.0 nTPM
Colon	3.0 nTPM
Rectum	2.2 nTPM
Small intestine	0.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC