Single cell type - FUBP1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FUBP1
Gene descriptionⁱ Full gene name according to HGNC.	Far upstream element binding protein 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

FUBP1 is part of cluster 10 Non-specific - Unknown function with confidenceⁱ 0.99
482 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TARDBP	TAR DNA binding protein	0.5836	10
HNRNPR	Heterogeneous nuclear ribonucleoprotein R	0.5775	10
GNL2	G protein nucleolar 2	0.5601	10
NAA15	N-alpha-acetyltransferase 15, NatA auxiliary subunit	0.5517	10
EWSR1	EWS RNA binding protein 1	0.5477	10
HNRNPA2B1	Heterogeneous nuclear ribonucleoprotein A2/B1	0.5308	10
ITSN2	Intersectin 2	0.5153	10
MAPRE1	Microtubule associated protein RP/EB family member 1	0.5080	10
SRSF1	Serine and arginine rich splicing factor 1	0.5033	39
HNRNPA3	Heterogeneous nuclear ribonucleoprotein A3	0.4968	10
HNRNPK	Heterogeneous nuclear ribonucleoprotein K	0.4920	10
GTPBP4	GTP binding protein 4	0.4863	44
NIPBL	NIPBL cohesin loading factor	0.4856	10
DNAJC2	DnaJ heat shock protein family (Hsp40) member C2	0.4830	10
MORC3	MORC family CW-type zinc finger 3	0.4772	10

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	38.6 nTPM
Adipose tissue	45.2 nTPM
Breast	32.1 nTPM

Alveolar cells type 1	73.7 nTPM
Lung	73.7 nTPM

Alveolar cells type 2	57.5 nTPM
Lung	57.5 nTPM

Astrocytes	48.0 nTPM
Brain	48.0 nTPM

B-cells	70.7 nTPM
Bone marrow	99.7 nTPM
Stomach	83.6 nTPM
Adipose tissue	80.7 nTPM
Spleen	80.6 nTPM
Lymph node	77.6 nTPM
PBMC	75.7 nTPM
Colon	67.1 nTPM
Breast	50.9 nTPM
Liver	48.7 nTPM
Kidney	42.9 nTPM

Dendritic cells	68.2 nTPM
Adipose tissue	108.6 nTPM
Breast	48.1 nTPM
PBMC	47.8 nTPM

Endothelial cells	52.0 nTPM
Lung	106.0 nTPM
Prostate	86.1 nTPM
Endometrium	62.6 nTPM
Skin	60.8 nTPM
Pancreas	54.0 nTPM
Esophagus	53.0 nTPM
Heart muscle	51.4 nTPM
Skeletal muscle	51.1 nTPM
Ovary	43.8 nTPM
Testis	35.3 nTPM
Breast	35.2 nTPM
Eye	30.7 nTPM
Liver	30.2 nTPM
Placenta	27.8 nTPM

Fibroblasts	49.0 nTPM
Lung	98.3 nTPM
Heart muscle	67.9 nTPM
Prostate	62.5 nTPM
Ovary	47.1 nTPM
Skeletal muscle	43.7 nTPM
Placenta	41.6 nTPM
Adipose tissue	39.3 nTPM
Skin	38.8 nTPM
Esophagus	37.2 nTPM
Stomach	35.6 nTPM
Breast	26.5 nTPM

Intestinal goblet cells	35.9 nTPM
Small intestine	41.2 nTPM
Rectum	33.8 nTPM
Colon	32.9 nTPM

Macrophages	41.8 nTPM
Bone marrow	65.0 nTPM
Adipose tissue	64.6 nTPM
Endometrium	58.4 nTPM
Skeletal muscle	56.5 nTPM
Lung	50.0 nTPM
Spleen	48.8 nTPM
Kidney	42.4 nTPM
Stomach	41.0 nTPM
Testis	37.8 nTPM
Breast	34.8 nTPM
Pancreas	33.2 nTPM
Prostate	32.0 nTPM
Esophagus	28.3 nTPM
Ovary	20.9 nTPM
PBMC	13.6 nTPM

Paneth cells	33.5 nTPM
Small intestine	33.8 nTPM
Rectum	33.8 nTPM
Colon	32.9 nTPM

Plasma cells	68.9 nTPM
Bone marrow	88.9 nTPM
Esophagus	67.8 nTPM
Adipose tissue	67.7 nTPM
Stomach	65.7 nTPM
Spleen	54.2 nTPM

Respiratory ciliated cells	73.2 nTPM
Lung	104.9 nTPM
Bronchus	41.6 nTPM

Smooth muscle cells	65.7 nTPM
Bronchus	223.9 nTPM
Heart muscle	78.2 nTPM
Ovary	60.4 nTPM
Skeletal muscle	57.0 nTPM
Adipose tissue	55.6 nTPM
Pancreas	53.4 nTPM
Endometrium	50.1 nTPM
Prostate	45.0 nTPM
Skin	40.1 nTPM
Esophagus	35.7 nTPM
Breast	23.3 nTPM

T-cells	72.1 nTPM
Lung	104.8 nTPM
Adipose tissue	89.8 nTPM
Colon	87.9 nTPM
Endometrium	84.8 nTPM
Bone marrow	83.3 nTPM
Stomach	79.4 nTPM
Lymph node	77.9 nTPM
Spleen	77.3 nTPM
PBMC	76.5 nTPM
Prostate	71.1 nTPM
Skeletal muscle	69.7 nTPM
Kidney	58.9 nTPM
Breast	57.3 nTPM
Skin	55.8 nTPM
Esophagus	52.4 nTPM
Liver	52.1 nTPM
Ovary	46.7 nTPM

Basal prostatic cells	107.0 nTPM
Prostate	107.0 nTPM

Basal respiratory cells	49.5 nTPM
Bronchus	49.5 nTPM

Cholangiocytes	24.3 nTPM
Liver	24.3 nTPM

Collecting duct cells	33.1 nTPM
Kidney	33.1 nTPM

Undifferentiated cells	37.8 nTPM
Colon	41.8 nTPM
Small intestine	40.0 nTPM
Rectum	31.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC