Single cell type - CCDC127 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CCDC127
Gene descriptionⁱ Full gene name according to HGNC.	Coiled-coil domain containing 127
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Plasma cells - Humoral immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HeLa)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CCDC127 is part of cluster 55 Plasma cells - Humoral immune response with confidenceⁱ 0.48
379 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TFG	Trafficking from ER to golgi regulator	0.5477	55
TM2D2	TM2 domain containing 2	0.5159	4
KAT5	Lysine acetyltransferase 5	0.4966	26
PRPSAP1	Phosphoribosyl pyrophosphate synthetase associated protein 1	0.4950	5
YIPF5	Yip1 domain family member 5	0.4922	55
PIGH	Phosphatidylinositol glycan anchor biosynthesis class H	0.4888	5
HTATIP2	HIV-1 Tat interactive protein 2	0.4817	53
AP5S1	Adaptor related protein complex 5 subunit sigma 1	0.4775	66
FASTKD5	FAST kinase domains 5	0.4681	66
GALNS	Galactosamine (N-acetyl)-6-sulfatase	0.4643	20
GLT8D1	Glycosyltransferase 8 domain containing 1	0.4602	66
YIPF3	Yip1 domain family member 3	0.4578	55
PLRG1	Pleiotropic regulator 1	0.4516	26
RIC8A	RIC8 guanine nucleotide exchange factor A	0.4509	55
RANBP3	RAN binding protein 3	0.4503	66

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	13.8 nTPM
Breast	17.6 nTPM
Adipose tissue	10.0 nTPM

Alveolar cells type 1	16.0 nTPM
Lung	16.0 nTPM

Alveolar cells type 2	10.4 nTPM
Lung	10.4 nTPM

Astrocytes	3.9 nTPM
Brain	3.9 nTPM

B-cells	7.8 nTPM
Liver	16.0 nTPM
Bone marrow	11.5 nTPM
Colon	11.2 nTPM
PBMC	8.5 nTPM
Breast	6.6 nTPM
Spleen	6.5 nTPM
Stomach	5.0 nTPM
Kidney	4.8 nTPM
Adipose tissue	4.5 nTPM
Lymph node	3.6 nTPM

Dendritic cells	13.9 nTPM
Breast	14.9 nTPM
Adipose tissue	14.8 nTPM
PBMC	12.0 nTPM

Endothelial cells	14.8 nTPM
Lung	24.9 nTPM
Placenta	23.3 nTPM
Pancreas	23.1 nTPM
Ovary	18.4 nTPM
Heart muscle	16.9 nTPM
Endometrium	13.7 nTPM
Testis	12.8 nTPM
Breast	12.5 nTPM
Prostate	12.1 nTPM
Liver	11.9 nTPM
Esophagus	10.3 nTPM
Skin	9.5 nTPM
Skeletal muscle	9.5 nTPM
Eye	8.1 nTPM

Fibroblasts	19.9 nTPM
Placenta	35.6 nTPM
Adipose tissue	27.4 nTPM
Breast	26.3 nTPM
Skeletal muscle	24.7 nTPM
Esophagus	22.8 nTPM
Ovary	17.9 nTPM
Heart muscle	17.7 nTPM
Prostate	15.0 nTPM
Skin	13.9 nTPM
Stomach	11.9 nTPM
Lung	5.6 nTPM

Intestinal goblet cells	9.6 nTPM
Small intestine	12.7 nTPM
Colon	8.5 nTPM
Rectum	7.4 nTPM

Macrophages	10.6 nTPM
PBMC	27.3 nTPM
Ovary	17.1 nTPM
Pancreas	15.3 nTPM
Prostate	13.8 nTPM
Testis	12.2 nTPM
Breast	12.0 nTPM
Kidney	9.9 nTPM
Endometrium	9.9 nTPM
Skeletal muscle	8.3 nTPM
Lung	7.8 nTPM
Adipose tissue	7.1 nTPM
Esophagus	6.3 nTPM
Stomach	5.9 nTPM
Spleen	4.2 nTPM
Bone marrow	2.5 nTPM

Paneth cells	3.7 nTPM
Rectum	7.7 nTPM
Colon	3.3 nTPM
Small intestine	0.0 nTPM

Plasma cells	8.7 nTPM
Esophagus	12.3 nTPM
Spleen	11.1 nTPM
Stomach	8.3 nTPM
Bone marrow	6.6 nTPM
Adipose tissue	5.2 nTPM

Respiratory ciliated cells	19.3 nTPM
Lung	20.4 nTPM
Bronchus	18.3 nTPM

Smooth muscle cells	13.4 nTPM
Ovary	21.3 nTPM
Heart muscle	20.8 nTPM
Pancreas	17.7 nTPM
Breast	16.6 nTPM
Skeletal muscle	13.2 nTPM
Adipose tissue	12.5 nTPM
Endometrium	11.7 nTPM
Bronchus	10.3 nTPM
Skin	8.4 nTPM
Esophagus	7.8 nTPM
Prostate	6.9 nTPM

T-cells	11.1 nTPM
Kidney	19.8 nTPM
Prostate	19.0 nTPM
Liver	15.4 nTPM
Adipose tissue	14.7 nTPM
PBMC	13.5 nTPM
Breast	12.1 nTPM
Bone marrow	11.6 nTPM
Ovary	11.1 nTPM
Skin	10.5 nTPM
Endometrium	9.8 nTPM
Colon	9.0 nTPM
Skeletal muscle	9.0 nTPM
Stomach	8.1 nTPM
Spleen	7.4 nTPM
Esophagus	6.6 nTPM
Lung	6.1 nTPM
Lymph node	4.7 nTPM

Basal keratinocytes	14.1 nTPM
Skin	14.1 nTPM

Basal prostatic cells	13.6 nTPM
Prostate	13.6 nTPM

Basal respiratory cells	29.2 nTPM
Bronchus	29.2 nTPM

Basal squamous epithelial cells	10.2 nTPM
Esophagus	10.2 nTPM

Undifferentiated cells	7.6 nTPM
Small intestine	11.7 nTPM
Rectum	7.8 nTPM
Colon	3.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC