Single cell type - ISCA2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ISCA2
Gene descriptionⁱ Full gene name according to HGNC.	Iron-sulfur cluster assembly 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ISCA2 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 1
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
C1D	C1D nuclear receptor corepressor	0.5996	39
SNAPC5	Small nuclear RNA activating complex polypeptide 5	0.5637	39
FAM104B	Family with sequence similarity 104 member B	0.5520	49
MRPL13	Mitochondrial ribosomal protein L13	0.5503	26
TTC1	Tetratricopeptide repeat domain 1	0.5284	39
TMEM126B	Transmembrane protein 126B	0.5239	39
MRPS10	Mitochondrial ribosomal protein S10	0.5187	39
RPA3	Replication protein A3	0.5187	39
MRPS23	Mitochondrial ribosomal protein S23	0.5119	39
PPCS	Phosphopantothenoylcysteine synthetase	0.5075	39
SRP9	Signal recognition particle 9	0.5057	39
GABARAPL2	GABA type A receptor associated protein like 2	0.4981	39
TIMMDC1	Translocase of inner mitochondrial membrane domain containing 1	0.4909	39
GMPR2	Guanosine monophosphate reductase 2	0.4895	39
TCEAL8	Transcription elongation factor A like 8	0.4830	39

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	25.2 nTPM
Breast	36.9 nTPM
Adipose tissue	13.6 nTPM

Alveolar cells type 1	19.2 nTPM
Lung	19.2 nTPM

Alveolar cells type 2	20.4 nTPM
Lung	20.4 nTPM

Astrocytes	7.2 nTPM
Brain	7.2 nTPM

B-cells	36.2 nTPM
Kidney	52.4 nTPM
PBMC	51.3 nTPM
Liver	48.8 nTPM
Bone marrow	48.3 nTPM
Colon	39.9 nTPM
Spleen	33.6 nTPM
Stomach	30.0 nTPM
Breast	26.8 nTPM
Lymph node	18.0 nTPM
Adipose tissue	13.5 nTPM

Dendritic cells	28.8 nTPM
PBMC	47.8 nTPM
Breast	24.8 nTPM
Adipose tissue	13.7 nTPM

Endothelial cells	27.2 nTPM
Heart muscle	47.5 nTPM
Placenta	45.5 nTPM
Testis	35.0 nTPM
Liver	33.0 nTPM
Eye	32.4 nTPM
Breast	28.1 nTPM
Esophagus	27.8 nTPM
Pancreas	27.0 nTPM
Ovary	24.3 nTPM
Skin	23.7 nTPM
Skeletal muscle	19.6 nTPM
Prostate	18.3 nTPM
Endometrium	16.0 nTPM
Lung	3.1 nTPM

Fibroblasts	28.8 nTPM
Heart muscle	66.8 nTPM
Placenta	61.5 nTPM
Ovary	29.9 nTPM
Breast	29.4 nTPM
Esophagus	27.6 nTPM
Prostate	22.5 nTPM
Stomach	22.3 nTPM
Adipose tissue	21.2 nTPM
Skin	16.3 nTPM
Skeletal muscle	15.1 nTPM
Lung	4.5 nTPM

Intestinal goblet cells	36.3 nTPM
Rectum	42.1 nTPM
Small intestine	35.3 nTPM
Colon	31.5 nTPM

Macrophages	30.4 nTPM
Pancreas	76.5 nTPM
Kidney	65.1 nTPM
Ovary	50.2 nTPM
Bone marrow	41.2 nTPM
Testis	29.7 nTPM
Breast	28.8 nTPM
PBMC	27.3 nTPM
Endometrium	26.6 nTPM
Prostate	24.1 nTPM
Spleen	21.8 nTPM
Esophagus	20.4 nTPM
Lung	14.5 nTPM
Stomach	11.7 nTPM
Skeletal muscle	10.3 nTPM
Adipose tissue	7.4 nTPM

Paneth cells	50.8 nTPM
Small intestine	63.8 nTPM
Rectum	45.7 nTPM
Colon	42.8 nTPM

Plasma cells	25.0 nTPM
Spleen	38.1 nTPM
Bone marrow	36.2 nTPM
Stomach	31.1 nTPM
Adipose tissue	13.6 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	78.6 nTPM
Bronchus	96.0 nTPM
Lung	61.2 nTPM

Smooth muscle cells	25.1 nTPM
Ovary	50.0 nTPM
Heart muscle	48.7 nTPM
Bronchus	43.4 nTPM
Pancreas	37.2 nTPM
Breast	19.9 nTPM
Esophagus	15.5 nTPM
Prostate	14.0 nTPM
Skin	12.9 nTPM
Endometrium	12.5 nTPM
Adipose tissue	11.6 nTPM
Skeletal muscle	9.8 nTPM

T-cells	30.7 nTPM
Kidney	64.3 nTPM
Bone marrow	51.2 nTPM
Spleen	43.6 nTPM
PBMC	43.5 nTPM
Liver	40.1 nTPM
Stomach	30.9 nTPM
Ovary	28.9 nTPM
Lung	27.4 nTPM
Skin	26.2 nTPM
Esophagus	26.2 nTPM
Breast	25.7 nTPM
Colon	24.2 nTPM
Lymph node	24.0 nTPM
Prostate	19.0 nTPM
Endometrium	16.2 nTPM
Adipose tissue	15.5 nTPM
Skeletal muscle	15.2 nTPM

Basal keratinocytes	15.4 nTPM
Skin	15.4 nTPM

Basal respiratory cells	74.9 nTPM
Bronchus	74.9 nTPM

Cholangiocytes	22.8 nTPM
Liver	22.8 nTPM

Collecting duct cells	33.1 nTPM
Kidney	33.1 nTPM

Undifferentiated cells	42.3 nTPM
Rectum	50.2 nTPM
Small intestine	45.1 nTPM
Colon	31.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC