Single cell type - TMEM126B - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TMEM126B
Gene descriptionⁱ Full gene name according to HGNC.	Transmembrane protein 126B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TMEM126B is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 1
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SRP9	Signal recognition particle 9	0.6061	39
LAMTOR5	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	0.5804	67
MRPL13	Mitochondrial ribosomal protein L13	0.5714	26
COX7A2L	Cytochrome c oxidase subunit 7A2 like	0.5594	39
NDUFA4	NDUFA4 mitochondrial complex associated	0.5549	39
PDZD11	PDZ domain containing 11	0.5415	39
SDHC	Succinate dehydrogenase complex subunit C	0.5316	67
POP5	POP5 homolog, ribonuclease P/MRP subunit	0.5316	39
NDUFB2	NADH:ubiquinone oxidoreductase subunit B2	0.5303	39
RPA3	Replication protein A3	0.5288	39
ISCA2	Iron-sulfur cluster assembly 2	0.5239	39
TCEAL8	Transcription elongation factor A like 8	0.5167	39
LSM3	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated	0.5163	67
BOLA3	BolA family member 3	0.5136	39
NFU1	NFU1 iron-sulfur cluster scaffold	0.5131	39

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	44.9 nTPM
Breast	54.3 nTPM
Adipose tissue	35.6 nTPM

Alveolar cells type 1	22.4 nTPM
Lung	22.4 nTPM

Alveolar cells type 2	40.7 nTPM
Lung	40.7 nTPM

Astrocytes	16.6 nTPM
Brain	16.6 nTPM

B-cells	34.6 nTPM
Kidney	52.4 nTPM
Liver	48.9 nTPM
PBMC	45.7 nTPM
Colon	38.3 nTPM
Adipose tissue	31.1 nTPM
Spleen	31.1 nTPM
Bone marrow	25.3 nTPM
Lymph node	24.9 nTPM
Stomach	24.1 nTPM
Breast	24.1 nTPM

Dendritic cells	54.2 nTPM
PBMC	67.8 nTPM
Breast	51.7 nTPM
Adipose tissue	43.1 nTPM

Endothelial cells	46.1 nTPM
Testis	74.1 nTPM
Pancreas	61.8 nTPM
Placenta	58.5 nTPM
Skin	56.3 nTPM
Breast	50.5 nTPM
Lung	46.8 nTPM
Heart muscle	43.8 nTPM
Prostate	41.4 nTPM
Ovary	39.8 nTPM
Liver	38.5 nTPM
Skeletal muscle	36.0 nTPM
Eye	35.6 nTPM
Endometrium	33.5 nTPM
Esophagus	29.1 nTPM

Fibroblasts	45.1 nTPM
Skin	60.2 nTPM
Heart muscle	53.8 nTPM
Breast	52.4 nTPM
Placenta	51.1 nTPM
Adipose tissue	48.9 nTPM
Ovary	48.4 nTPM
Skeletal muscle	42.2 nTPM
Lung	36.9 nTPM
Esophagus	36.1 nTPM
Prostate	35.4 nTPM
Stomach	31.2 nTPM

Intestinal goblet cells	41.3 nTPM
Colon	42.9 nTPM
Small intestine	42.9 nTPM
Rectum	38.1 nTPM

Macrophages	43.5 nTPM
Pancreas	86.8 nTPM
Testis	75.0 nTPM
Kidney	60.5 nTPM
Ovary	56.8 nTPM
Lung	46.6 nTPM
Breast	46.4 nTPM
Bone marrow	45.0 nTPM
Prostate	44.7 nTPM
Endometrium	38.6 nTPM
Spleen	37.4 nTPM
Esophagus	31.5 nTPM
Adipose tissue	28.7 nTPM
Skeletal muscle	24.1 nTPM
Stomach	17.6 nTPM
PBMC	13.6 nTPM

Paneth cells	52.8 nTPM
Small intestine	60.1 nTPM
Rectum	55.3 nTPM
Colon	42.8 nTPM

Plasma cells	22.4 nTPM
Spleen	31.8 nTPM
Bone marrow	31.3 nTPM
Adipose tissue	21.3 nTPM
Stomach	21.3 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	51.3 nTPM
Lung	52.5 nTPM
Bronchus	50.1 nTPM

Smooth muscle cells	43.8 nTPM
Pancreas	74.6 nTPM
Heart muscle	68.8 nTPM
Breast	49.4 nTPM
Skin	48.5 nTPM
Prostate	40.0 nTPM
Ovary	38.1 nTPM
Esophagus	35.7 nTPM
Skeletal muscle	34.0 nTPM
Adipose tissue	33.2 nTPM
Endometrium	31.9 nTPM
Bronchus	28.0 nTPM

T-cells	49.7 nTPM
Kidney	78.7 nTPM
Skin	75.1 nTPM
PBMC	68.6 nTPM
Colon	66.1 nTPM
Liver	65.4 nTPM
Lung	63.8 nTPM
Ovary	57.8 nTPM
Prostate	56.8 nTPM
Breast	44.4 nTPM
Spleen	42.7 nTPM
Bone marrow	39.9 nTPM
Adipose tissue	39.7 nTPM
Lymph node	33.5 nTPM
Skeletal muscle	32.4 nTPM
Stomach	31.0 nTPM
Endometrium	29.9 nTPM
Esophagus	19.7 nTPM

Basal keratinocytes	26.1 nTPM
Skin	26.1 nTPM

Basal prostatic cells	32.2 nTPM
Prostate	32.2 nTPM

Basal respiratory cells	80.8 nTPM
Bronchus	80.8 nTPM

Basal squamous epithelial cells	22.8 nTPM
Esophagus	22.8 nTPM

Undifferentiated cells	52.0 nTPM
Small intestine	63.2 nTPM
Colon	51.9 nTPM
Rectum	40.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC