Single cell type - TAF10 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TAF10
Gene descriptionⁱ Full gene name according to HGNC.	TATA-box binding protein associated factor 10
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Late spermatids, Early spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Late spermatids, Early spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TAF10 is part of cluster 10 Non-specific - Unknown function with confidenceⁱ 1
482 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ATXN7L3	Ataxin 7 like 3	0.7884	10
HSPA1L	Heat shock protein family A (Hsp70) member 1 like	0.7437	31
UBAP2L	Ubiquitin associated protein 2 like	0.6676	10
EXOC3	Exocyst complex component 3	0.6319	10
SMIM35	Small integral membrane protein 35	0.6270	10
LSM12	LSM12 homolog	0.6179	34
CDC34	Cell division cycle 34, ubiqiutin conjugating enzyme	0.5972	10
UBE2Q1	Ubiquitin conjugating enzyme E2 Q1	0.5925	10
PLEKHO1	Pleckstrin homology domain containing O1	0.5730	10
PF4V1	Platelet factor 4 variant 1	0.5680	10
ETV3L	ETS variant transcription factor 3 like	0.5667	10
PPP1R2B	PPP1R2 family member B	0.5593	10
ACTBL2	Actin beta like 2	0.5573	10
PGP	Phosphoglycolate phosphatase	0.5539	31
FES	FES proto-oncogene, tyrosine kinase	0.5479	10

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	106.4 nTPM
Breast	137.8 nTPM
Adipose tissue	75.0 nTPM

Alveolar cells type 1	3.2 nTPM
Lung	3.2 nTPM

Alveolar cells type 2	23.3 nTPM
Lung	23.3 nTPM

Astrocytes	6.2 nTPM
Brain	6.2 nTPM

B-cells	60.1 nTPM
Adipose tissue	150.9 nTPM
Breast	122.9 nTPM
Liver	76.2 nTPM
Bone marrow	48.3 nTPM
Spleen	45.0 nTPM
Lymph node	40.9 nTPM
Stomach	38.6 nTPM
Colon	33.5 nTPM
PBMC	29.9 nTPM
Kidney	14.3 nTPM

Dendritic cells	130.7 nTPM
Adipose tissue	171.7 nTPM
Breast	152.7 nTPM
PBMC	67.8 nTPM

Endothelial cells	39.3 nTPM
Breast	79.3 nTPM
Endometrium	70.2 nTPM
Ovary	55.1 nTPM
Esophagus	49.0 nTPM
Prostate	48.4 nTPM
Testis	36.7 nTPM
Skeletal muscle	36.2 nTPM
Heart muscle	34.6 nTPM
Eye	33.2 nTPM
Liver	33.0 nTPM
Skin	32.0 nTPM
Placenta	26.7 nTPM
Lung	12.5 nTPM
Pancreas	3.9 nTPM

Fibroblasts	43.0 nTPM
Ovary	83.5 nTPM
Adipose tissue	83.5 nTPM
Breast	78.5 nTPM
Esophagus	42.1 nTPM
Skeletal muscle	33.3 nTPM
Prostate	31.6 nTPM
Heart muscle	31.0 nTPM
Skin	28.5 nTPM
Placenta	28.2 nTPM
Stomach	25.3 nTPM
Lung	7.8 nTPM

Intestinal goblet cells	50.8 nTPM
Colon	60.8 nTPM
Rectum	49.6 nTPM
Small intestine	42.0 nTPM

Macrophages	91.2 nTPM
Adipose tissue	173.9 nTPM
Breast	168.8 nTPM
Ovary	145.9 nTPM
Endometrium	141.4 nTPM
Bone marrow	96.2 nTPM
Prostate	86.0 nTPM
Stomach	82.1 nTPM
Spleen	77.8 nTPM
Skeletal muscle	73.9 nTPM
Kidney	73.4 nTPM
Esophagus	59.8 nTPM
Pancreas	58.7 nTPM
PBMC	54.6 nTPM
Testis	41.2 nTPM
Lung	33.8 nTPM

Paneth cells	68.5 nTPM
Colon	108.7 nTPM
Rectum	59.2 nTPM
Small intestine	37.6 nTPM

Plasma cells	89.6 nTPM
Spleen	136.3 nTPM
Bone marrow	105.4 nTPM
Adipose tissue	90.4 nTPM
Stomach	60.6 nTPM
Esophagus	55.5 nTPM

Respiratory ciliated cells	14.0 nTPM
Lung	16.0 nTPM
Bronchus	11.9 nTPM

Smooth muscle cells	50.0 nTPM
Bronchus	168.0 nTPM
Ovary	107.6 nTPM
Breast	56.9 nTPM
Pancreas	46.0 nTPM
Endometrium	45.3 nTPM
Adipose tissue	32.4 nTPM
Esophagus	23.3 nTPM
Prostate	18.7 nTPM
Skeletal muscle	18.3 nTPM
Heart muscle	17.3 nTPM
Skin	15.7 nTPM

T-cells	65.0 nTPM
Adipose tissue	166.0 nTPM
Breast	130.3 nTPM
Ovary	100.1 nTPM
Endometrium	84.5 nTPM
Skeletal muscle	74.6 nTPM
Stomach	67.1 nTPM
Esophagus	58.9 nTPM
Bone marrow	58.7 nTPM
Liver	50.7 nTPM
PBMC	49.9 nTPM
Spleen	49.7 nTPM
Lymph node	49.1 nTPM
Kidney	47.2 nTPM
Colon	46.1 nTPM
Skin	36.4 nTPM
Prostate	23.6 nTPM
Lung	12.2 nTPM

Basal keratinocytes	21.4 nTPM
Skin	21.4 nTPM

Basal prostatic cells	56.8 nTPM
Prostate	56.8 nTPM

Basal respiratory cells	9.4 nTPM
Bronchus	9.4 nTPM

Basal squamous epithelial cells	32.5 nTPM
Esophagus	32.5 nTPM

Undifferentiated cells	44.2 nTPM
Small intestine	47.6 nTPM
Rectum	45.2 nTPM
Colon	39.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC