Single cell type - POP5 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	POP5
Gene descriptionⁱ Full gene name according to HGNC.	POP5 homolog, ribonuclease P/MRP subunit
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Distal tubular cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Distal tubular cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

POP5 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 1
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MRPL40	Mitochondrial ribosomal protein L40	0.6488	39
PRDX3	Peroxiredoxin 3	0.6285	39
ACAD8	Acyl-CoA dehydrogenase family member 8	0.6285	39
MRPL13	Mitochondrial ribosomal protein L13	0.6173	26
COA3	Cytochrome c oxidase assembly factor 3	0.6101	67
RPA3	Replication protein A3	0.5925	39
COQ3	Coenzyme Q3, methyltransferase	0.5852	39
SRP9	Signal recognition particle 9	0.5735	39
CHCHD4	Coiled-coil-helix-coiled-coil-helix domain containing 4	0.5680	39
MRPL16	Mitochondrial ribosomal protein L16	0.5639	39
MRPL19	Mitochondrial ribosomal protein L19	0.5634	39
CHCHD1	Coiled-coil-helix-coiled-coil-helix domain containing 1	0.5586	39
SDHC	Succinate dehydrogenase complex subunit C	0.5534	67
HINT2	Histidine triad nucleotide binding protein 2	0.5503	39
MRPL27	Mitochondrial ribosomal protein L27	0.5468	39

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	24.2 nTPM
Breast	33.1 nTPM
Adipose tissue	15.3 nTPM

Alveolar cells type 1	12.8 nTPM
Lung	12.8 nTPM

Alveolar cells type 2	27.6 nTPM
Lung	27.6 nTPM

Astrocytes	10.1 nTPM
Brain	10.1 nTPM

B-cells	47.8 nTPM
Liver	98.4 nTPM
Breast	54.9 nTPM
PBMC	54.3 nTPM
Kidney	52.4 nTPM
Spleen	47.5 nTPM
Bone marrow	44.9 nTPM
Stomach	40.4 nTPM
Colon	35.1 nTPM
Lymph node	32.1 nTPM
Adipose tissue	18.6 nTPM

Dendritic cells	49.3 nTPM
PBMC	63.8 nTPM
Breast	52.1 nTPM
Adipose tissue	32.0 nTPM

Endothelial cells	25.4 nTPM
Placenta	40.4 nTPM
Heart muscle	37.7 nTPM
Eye	34.0 nTPM
Ovary	29.1 nTPM
Testis	29.0 nTPM
Esophagus	27.3 nTPM
Breast	25.1 nTPM
Endometrium	23.6 nTPM
Skin	23.5 nTPM
Liver	20.2 nTPM
Pancreas	19.3 nTPM
Lung	18.7 nTPM
Skeletal muscle	16.4 nTPM
Prostate	12.0 nTPM

Fibroblasts	33.8 nTPM
Heart muscle	80.4 nTPM
Ovary	38.4 nTPM
Esophagus	38.4 nTPM
Breast	34.6 nTPM
Stomach	31.2 nTPM
Adipose tissue	28.4 nTPM
Skeletal muscle	28.2 nTPM
Placenta	27.7 nTPM
Lung	25.7 nTPM
Skin	22.7 nTPM
Prostate	16.5 nTPM

Intestinal goblet cells	30.5 nTPM
Colon	42.2 nTPM
Rectum	26.9 nTPM
Small intestine	22.5 nTPM

Macrophages	35.7 nTPM
Kidney	59.7 nTPM
Pancreas	58.7 nTPM
Breast	48.3 nTPM
Prostate	45.8 nTPM
Endometrium	45.5 nTPM
Stomach	38.1 nTPM
Lung	32.8 nTPM
Esophagus	31.5 nTPM
Testis	29.7 nTPM
Ovary	28.5 nTPM
Bone marrow	27.5 nTPM
PBMC	27.3 nTPM
Skeletal muscle	23.1 nTPM
Spleen	22.8 nTPM
Adipose tissue	16.6 nTPM

Paneth cells	21.9 nTPM
Rectum	32.7 nTPM
Small intestine	26.3 nTPM
Colon	6.5 nTPM

Plasma cells	56.8 nTPM
Spleen	92.6 nTPM
Bone marrow	59.4 nTPM
Stomach	57.1 nTPM
Esophagus	55.5 nTPM
Adipose tissue	19.4 nTPM

Respiratory ciliated cells	45.2 nTPM
Bronchus	62.8 nTPM
Lung	27.7 nTPM

Smooth muscle cells	39.4 nTPM
Bronchus	91.5 nTPM
Heart muscle	78.3 nTPM
Pancreas	57.7 nTPM
Esophagus	35.7 nTPM
Breast	35.0 nTPM
Skeletal muscle	26.2 nTPM
Adipose tissue	25.3 nTPM
Endometrium	21.9 nTPM
Skin	21.6 nTPM
Prostate	20.3 nTPM
Ovary	19.4 nTPM

T-cells	46.1 nTPM
Kidney	69.8 nTPM
Lung	59.2 nTPM
Esophagus	58.9 nTPM
Ovary	55.6 nTPM
PBMC	54.3 nTPM
Stomach	54.0 nTPM
Breast	50.9 nTPM
Bone marrow	49.8 nTPM
Liver	49.2 nTPM
Spleen	48.7 nTPM
Colon	46.1 nTPM
Lymph node	42.1 nTPM
Endometrium	35.7 nTPM
Skeletal muscle	31.4 nTPM
Skin	30.9 nTPM
Adipose tissue	28.2 nTPM
Prostate	19.0 nTPM

Basal keratinocytes	19.6 nTPM
Skin	19.6 nTPM

Basal prostatic cells	38.6 nTPM
Prostate	38.6 nTPM

Basal respiratory cells	83.7 nTPM
Bronchus	83.7 nTPM

Basal squamous epithelial cells	34.1 nTPM
Esophagus	34.1 nTPM

Undifferentiated cells	44.2 nTPM
Colon	55.7 nTPM
Small intestine	39.2 nTPM
Rectum	37.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC