Single cell type - TMEM126A - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TMEM126A
Gene descriptionⁱ Full gene name according to HGNC.	Transmembrane protein 126A
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TMEM126A is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 1
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MRPL36	Mitochondrial ribosomal protein L36	0.7075	39
MRPL51	Mitochondrial ribosomal protein L51	0.6305	39
COX7A2	Cytochrome c oxidase subunit 7A2	0.6273	39
NDUFB4	NADH:ubiquinone oxidoreductase subunit B4	0.5877	39
UQCRFS1	Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1	0.5854	39
MDH2	Malate dehydrogenase 2	0.5627	39
MRPL42	Mitochondrial ribosomal protein L42	0.5578	39
SNAPC5	Small nuclear RNA activating complex polypeptide 5	0.5488	39
NTPCR	Nucleoside-triphosphatase, cancer-related	0.5191	39
TRAPPC3	Trafficking protein particle complex 3	0.5135	10
MRPS5	Mitochondrial ribosomal protein S5	0.5104	39
C1orf43	Chromosome 1 open reading frame 43	0.4990	39
UQCR10	Ubiquinol-cytochrome c reductase, complex III subunit X	0.4981	39
ZSCAN5A	Zinc finger and SCAN domain containing 5A	0.4969	34
THUMPD3	THUMP domain containing 3	0.4957	66

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	40.5 nTPM
Breast	50.2 nTPM
Adipose tissue	30.9 nTPM

Alveolar cells type 1	28.9 nTPM
Lung	28.9 nTPM

Alveolar cells type 2	24.3 nTPM
Lung	24.3 nTPM

Astrocytes	12.7 nTPM
Brain	12.7 nTPM

B-cells	39.6 nTPM
Liver	78.8 nTPM
PBMC	47.1 nTPM
Breast	46.8 nTPM
Colon	44.8 nTPM
Spleen	41.5 nTPM
Stomach	40.0 nTPM
Bone marrow	28.6 nTPM
Adipose tissue	26.6 nTPM
Lymph node	23.0 nTPM
Kidney	19.0 nTPM

Dendritic cells	38.5 nTPM
Breast	46.7 nTPM
Adipose tissue	36.9 nTPM
PBMC	31.8 nTPM

Endothelial cells	36.7 nTPM
Placenta	54.6 nTPM
Pancreas	54.0 nTPM
Breast	48.6 nTPM
Prostate	43.0 nTPM
Testis	42.9 nTPM
Skin	40.6 nTPM
Ovary	33.2 nTPM
Lung	31.2 nTPM
Skeletal muscle	30.6 nTPM
Esophagus	28.2 nTPM
Eye	26.7 nTPM
Heart muscle	26.6 nTPM
Liver	26.6 nTPM
Endometrium	26.3 nTPM

Fibroblasts	40.8 nTPM
Placenta	54.5 nTPM
Heart muscle	47.6 nTPM
Ovary	45.9 nTPM
Prostate	42.4 nTPM
Adipose tissue	41.8 nTPM
Stomach	40.1 nTPM
Skin	39.5 nTPM
Skeletal muscle	35.6 nTPM
Esophagus	34.8 nTPM
Breast	33.7 nTPM
Lung	33.5 nTPM

Intestinal goblet cells	46.6 nTPM
Rectum	50.1 nTPM
Colon	49.4 nTPM
Small intestine	40.3 nTPM

Macrophages	48.4 nTPM
Pancreas	86.8 nTPM
Kidney	79.4 nTPM
Prostate	76.8 nTPM
Ovary	59.3 nTPM
Lung	58.5 nTPM
Stomach	49.8 nTPM
Testis	47.7 nTPM
Spleen	47.7 nTPM
Breast	44.4 nTPM
Endometrium	42.4 nTPM
Skeletal muscle	37.6 nTPM
Esophagus	34.6 nTPM
Adipose tissue	30.6 nTPM
Bone marrow	30.0 nTPM
PBMC	0.0 nTPM

Paneth cells	34.8 nTPM
Rectum	54.3 nTPM
Small intestine	33.8 nTPM
Colon	16.5 nTPM

Plasma cells	45.4 nTPM
Spleen	75.5 nTPM
Bone marrow	61.0 nTPM
Stomach	49.9 nTPM
Esophagus	24.6 nTPM
Adipose tissue	16.1 nTPM

Respiratory ciliated cells	39.7 nTPM
Bronchus	40.0 nTPM
Lung	39.4 nTPM

Smooth muscle cells	40.9 nTPM
Pancreas	87.3 nTPM
Heart muscle	60.8 nTPM
Prostate	57.9 nTPM
Ovary	39.7 nTPM
Breast	39.2 nTPM
Skeletal muscle	36.5 nTPM
Esophagus	31.0 nTPM
Skin	27.5 nTPM
Bronchus	24.3 nTPM
Endometrium	24.2 nTPM
Adipose tissue	22.0 nTPM

T-cells	42.1 nTPM
Kidney	64.3 nTPM
Ovary	55.6 nTPM
Colon	50.8 nTPM
Lung	45.6 nTPM
Breast	43.8 nTPM
Skin	43.7 nTPM
Liver	43.6 nTPM
PBMC	43.3 nTPM
Prostate	42.6 nTPM
Spleen	41.1 nTPM
Stomach	39.3 nTPM
Adipose tissue	37.9 nTPM
Endometrium	34.7 nTPM
Lymph node	33.9 nTPM
Esophagus	32.8 nTPM
Skeletal muscle	31.9 nTPM
Bone marrow	30.6 nTPM

Basal keratinocytes	31.7 nTPM
Skin	31.7 nTPM

Basal prostatic cells	55.3 nTPM
Prostate	55.3 nTPM

Basal respiratory cells	87.9 nTPM
Bronchus	87.9 nTPM

Basal squamous epithelial cells	29.6 nTPM
Esophagus	29.6 nTPM

Undifferentiated cells	57.1 nTPM
Small intestine	66.5 nTPM
Rectum	60.5 nTPM
Colon	44.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC