Single cell type - PRKAG1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PRKAG1
Gene descriptionⁱ Full gene name according to HGNC.	Protein kinase AMP-activated non-catalytic subunit gamma 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	FDA approved drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	14

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (OE19)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PRKAG1 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 1
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SPAG7	Sperm associated antigen 7	0.5466	26
PDHB	Pyruvate dehydrogenase E1 subunit beta	0.5399	39
GPKOW	G-patch domain and KOW motifs	0.5204	63
ABCF3	ATP binding cassette subfamily F member 3	0.5154	39
ATP6V1E1	ATPase H+ transporting V1 subunit E1	0.5100	7
POLR2G	RNA polymerase II subunit G	0.5029	26
IDH3B	Isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta	0.4902	39
ENO1	Enolase 1	0.4869	16
SDHAF2	Succinate dehydrogenase complex assembly factor 2	0.4848	39
NUBP1	Nucleotide binding protein 1	0.4819	3
TIMMDC1	Translocase of inner mitochondrial membrane domain containing 1	0.4792	39
DLD	Dihydrolipoamide dehydrogenase	0.4756	39
CHMP4A	Charged multivesicular body protein 4A	0.4714	63
POLR2E	RNA polymerase II, I and III subunit E	0.4668	3
NDUFA10	NADH:ubiquinone oxidoreductase subunit A10	0.4666	39

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	20.2 nTPM
Breast	22.4 nTPM
Adipose tissue	17.9 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	22.7 nTPM
Lung	22.7 nTPM

Astrocytes	16.6 nTPM
Brain	16.6 nTPM

B-cells	31.2 nTPM
Kidney	61.9 nTPM
Liver	53.1 nTPM
PBMC	41.4 nTPM
Colon	28.7 nTPM
Bone marrow	28.6 nTPM
Stomach	24.5 nTPM
Breast	22.8 nTPM
Adipose tissue	21.0 nTPM
Spleen	15.3 nTPM
Lymph node	14.2 nTPM

Dendritic cells	30.5 nTPM
PBMC	35.8 nTPM
Breast	29.9 nTPM
Adipose tissue	25.7 nTPM

Endothelial cells	21.9 nTPM
Placenta	34.1 nTPM
Testis	32.0 nTPM
Pancreas	30.9 nTPM
Eye	27.5 nTPM
Ovary	25.4 nTPM
Liver	22.0 nTPM
Skeletal muscle	21.7 nTPM
Breast	21.2 nTPM
Skin	21.1 nTPM
Prostate	18.5 nTPM
Endometrium	16.7 nTPM
Heart muscle	13.8 nTPM
Esophagus	12.3 nTPM
Lung	9.3 nTPM

Fibroblasts	26.7 nTPM
Placenta	43.6 nTPM
Adipose tissue	33.9 nTPM
Stomach	32.7 nTPM
Ovary	29.2 nTPM
Heart muscle	28.4 nTPM
Skin	27.6 nTPM
Skeletal muscle	25.9 nTPM
Esophagus	23.1 nTPM
Breast	21.9 nTPM
Prostate	16.9 nTPM
Lung	11.1 nTPM

Intestinal goblet cells	31.6 nTPM
Colon	42.2 nTPM
Small intestine	26.9 nTPM
Rectum	25.7 nTPM

Macrophages	26.7 nTPM
Testis	55.2 nTPM
Kidney	43.2 nTPM
Lung	34.6 nTPM
Ovary	32.1 nTPM
Breast	31.9 nTPM
Bone marrow	31.2 nTPM
Pancreas	30.7 nTPM
Prostate	28.7 nTPM
Adipose tissue	24.8 nTPM
Skeletal muscle	19.8 nTPM
Spleen	16.5 nTPM
Endometrium	14.7 nTPM
PBMC	13.6 nTPM
Stomach	11.7 nTPM
Esophagus	11.0 nTPM

Paneth cells	16.5 nTPM
Rectum	25.0 nTPM
Colon	13.2 nTPM
Small intestine	11.3 nTPM

Plasma cells	25.0 nTPM
Esophagus	30.7 nTPM
Stomach	27.0 nTPM
Spleen	25.9 nTPM
Bone marrow	24.7 nTPM
Adipose tissue	16.7 nTPM

Respiratory ciliated cells	19.2 nTPM
Bronchus	20.9 nTPM
Lung	17.5 nTPM

Smooth muscle cells	27.5 nTPM
Pancreas	69.7 nTPM
Skin	30.4 nTPM
Heart muscle	29.4 nTPM
Skeletal muscle	26.4 nTPM
Adipose tissue	25.8 nTPM
Breast	25.2 nTPM
Prostate	24.4 nTPM
Ovary	24.0 nTPM
Esophagus	21.7 nTPM
Endometrium	17.0 nTPM
Bronchus	8.5 nTPM

T-cells	26.3 nTPM
Kidney	70.5 nTPM
Liver	48.0 nTPM
PBMC	40.4 nTPM
Colon	29.0 nTPM
Bone marrow	28.9 nTPM
Lung	28.8 nTPM
Stomach	28.6 nTPM
Skin	25.4 nTPM
Spleen	22.4 nTPM
Breast	21.3 nTPM
Ovary	20.1 nTPM
Skeletal muscle	19.9 nTPM
Adipose tissue	18.0 nTPM
Lymph node	17.5 nTPM
Prostate	14.2 nTPM
Endometrium	14.1 nTPM
Esophagus	0.0 nTPM

Basal keratinocytes	20.0 nTPM
Skin	20.0 nTPM

Basal prostatic cells	30.3 nTPM
Prostate	30.3 nTPM

Basal respiratory cells	64.5 nTPM
Bronchus	64.5 nTPM

Basal squamous epithelial cells	11.4 nTPM
Esophagus	11.4 nTPM

Undifferentiated cells	32.2 nTPM
Colon	34.9 nTPM
Small intestine	34.5 nTPM
Rectum	27.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC