Single cell type - SNRPE - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SNRPE
Gene descriptionⁱ Full gene name according to HGNC.	Small nuclear ribonucleoprotein polypeptide E
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Translation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

SNRPE is part of cluster 32 Non-specific - Translation with confidenceⁱ 1
175 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
RPL23	Ribosomal protein L23	0.7872	32
SNRPF	Small nuclear ribonucleoprotein polypeptide F	0.7547	32
RPS20	Ribosomal protein S20	0.7043	32
SNRPD1	Small nuclear ribonucleoprotein D1 polypeptide	0.6965	12
RPL27	Ribosomal protein L27	0.6454	32
RPS11	Ribosomal protein S11	0.6425	32
EIF3M	Eukaryotic translation initiation factor 3 subunit M	0.6283	10
RPL27A	Ribosomal protein L27a	0.6157	32
EIF3I	Eukaryotic translation initiation factor 3 subunit I	0.6002	10
RPL31	Ribosomal protein L31	0.5884	32
RPL13A	Ribosomal protein L13a	0.5831	32
DDX41	DEAD-box helicase 41	0.5817	10
EIF3L	Eukaryotic translation initiation factor 3 subunit L	0.5773	32
PSMG4	Proteasome assembly chaperone 4	0.5734	10
RPL7	Ribosomal protein L7	0.5719	32

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	125.2 nTPM
Breast	151.0 nTPM
Adipose tissue	99.4 nTPM

Alveolar cells type 1	128.2 nTPM
Lung	128.2 nTPM

Alveolar cells type 2	116.4 nTPM
Lung	116.4 nTPM

Astrocytes	5.5 nTPM
Brain	5.5 nTPM

B-cells	153.6 nTPM
Liver	379.7 nTPM
PBMC	219.9 nTPM
Kidney	219.0 nTPM
Colon	188.5 nTPM
Spleen	113.1 nTPM
Adipose tissue	96.2 nTPM
Stomach	88.1 nTPM
Breast	83.0 nTPM
Bone marrow	80.9 nTPM
Lymph node	67.2 nTPM

Basal squamous epithelial cells	101.3 nTPM
Esophagus	101.3 nTPM

Dendritic cells	146.1 nTPM
PBMC	259.0 nTPM
Breast	100.2 nTPM
Adipose tissue	79.1 nTPM

Endothelial cells	173.5 nTPM
Pancreas	378.4 nTPM
Placenta	292.2 nTPM
Prostate	244.4 nTPM
Testis	243.6 nTPM
Skin	219.0 nTPM
Lung	193.4 nTPM
Endometrium	156.2 nTPM
Breast	141.7 nTPM
Liver	136.7 nTPM
Ovary	123.5 nTPM
Skeletal muscle	119.0 nTPM
Esophagus	81.2 nTPM
Heart muscle	61.4 nTPM
Eye	38.0 nTPM

Enteroendocrine cells	163.4 nTPM
Colon	181.2 nTPM
Rectum	145.6 nTPM

Erythroid cells	176.9 nTPM
Bone marrow	193.4 nTPM
Liver	160.4 nTPM

Fibroblasts	159.3 nTPM
Placenta	303.3 nTPM
Ovary	229.1 nTPM
Lung	212.2 nTPM
Prostate	199.7 nTPM
Skin	187.6 nTPM
Breast	144.9 nTPM
Adipose tissue	138.1 nTPM
Skeletal muscle	120.1 nTPM
Stomach	86.1 nTPM
Heart muscle	75.0 nTPM
Esophagus	55.9 nTPM

Intestinal goblet cells	241.2 nTPM
Rectum	268.9 nTPM
Colon	263.8 nTPM
Small intestine	190.8 nTPM

Macrophages	117.6 nTPM
Kidney	254.8 nTPM
Pancreas	188.9 nTPM
Testis	187.7 nTPM
Endometrium	159.2 nTPM
Lung	156.8 nTPM
Prostate	142.2 nTPM
Skeletal muscle	117.3 nTPM
Adipose tissue	99.3 nTPM
Ovary	96.9 nTPM
Breast	95.4 nTPM
PBMC	68.2 nTPM
Spleen	64.3 nTPM
Bone marrow	60.0 nTPM
Stomach	38.1 nTPM
Esophagus	34.6 nTPM

Paneth cells	136.7 nTPM
Rectum	252.3 nTPM
Small intestine	105.1 nTPM
Colon	52.6 nTPM

Plasma cells	97.7 nTPM
Spleen	198.0 nTPM
Bone marrow	164.8 nTPM
Stomach	67.4 nTPM
Adipose tissue	33.6 nTPM
Esophagus	24.6 nTPM

Cholangiocytes	204.5 nTPM
Liver	204.5 nTPM

Collecting duct cells	128.8 nTPM
Kidney	128.8 nTPM

Cone photoreceptor cells	14.6 nTPM
Eye	14.6 nTPM

Cytotrophoblasts	454.6 nTPM
Placenta	454.6 nTPM

Respiratory ciliated cells	162.7 nTPM
Bronchus	189.7 nTPM
Lung	135.6 nTPM

Smooth muscle cells	240.4 nTPM
Bronchus	1043.9 nTPM
Pancreas	357.9 nTPM
Ovary	220.1 nTPM
Skin	192.9 nTPM
Prostate	160.4 nTPM
Skeletal muscle	146.4 nTPM
Endometrium	131.0 nTPM
Breast	126.6 nTPM
Adipose tissue	105.1 nTPM
Heart muscle	86.2 nTPM
Esophagus	74.4 nTPM

T-cells	126.2 nTPM
PBMC	254.9 nTPM
Kidney	200.5 nTPM
Skin	193.9 nTPM
Liver	193.2 nTPM
Colon	148.3 nTPM
Lung	127.6 nTPM
Prostate	118.3 nTPM
Endometrium	108.6 nTPM
Skeletal muscle	100.8 nTPM
Ovary	93.4 nTPM
Stomach	93.1 nTPM
Spleen	90.3 nTPM
Lymph node	88.3 nTPM
Bone marrow	87.3 nTPM
Breast	85.5 nTPM
Adipose tissue	82.5 nTPM
Esophagus	78.6 nTPM

Undifferentiated cells	313.8 nTPM
Colon	340.1 nTPM
Small intestine	323.3 nTPM
Rectum	278.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC