Single cell type - PSMG4 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PSMG4
Gene descriptionⁱ Full gene name according to HGNC.	Proteasome assembly chaperone 4
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PSMG4 is part of cluster 10 Non-specific - Unknown function with confidenceⁱ 1
482 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CUEDC2	CUE domain containing 2	0.6815	10
DNAJC19	DnaJ heat shock protein family (Hsp40) member C19	0.6808	39
PDCD2L	Programmed cell death 2 like	0.6752	10
ZNF90	Zinc finger protein 90	0.6737	10
TBPL2	TATA-box binding protein like 2	0.6709	10
HNRNPCL1	Heterogeneous nuclear ribonucleoprotein C like 1	0.6631	10
DCAF8L2	DDB1 and CUL4 associated factor 8 like 2	0.6402	10
POTEF	POTE ankyrin domain family member F	0.6265	10
EIF3I	Eukaryotic translation initiation factor 3 subunit I	0.5923	10
ANP32D	Acidic nuclear phosphoprotein 32 family member D	0.5920	10
TSN	Translin	0.5873	10
ESD	Esterase D	0.5788	10
ZMAT5	Zinc finger matrin-type 5	0.5782	10
SNRPE	Small nuclear ribonucleoprotein polypeptide E	0.5734	32
SUMO2	Small ubiquitin like modifier 2	0.5728	10

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	45.2 nTPM
Breast	52.6 nTPM
Adipose tissue	38.0 nTPM

Alveolar cells type 1	22.4 nTPM
Lung	22.4 nTPM

Alveolar cells type 2	21.2 nTPM
Lung	21.2 nTPM

Astrocytes	18.6 nTPM
Brain	18.6 nTPM

B-cells	25.3 nTPM
PBMC	51.3 nTPM
Kidney	47.6 nTPM
Liver	30.6 nTPM
Spleen	22.2 nTPM
Bone marrow	22.1 nTPM
Breast	18.7 nTPM
Adipose tissue	16.5 nTPM
Stomach	15.0 nTPM
Lymph node	14.8 nTPM
Colon	14.4 nTPM

Dendritic cells	15.2 nTPM
Breast	17.1 nTPM
Adipose tissue	16.6 nTPM
PBMC	12.0 nTPM

Endothelial cells	35.2 nTPM
Placenta	52.8 nTPM
Breast	48.7 nTPM
Esophagus	44.3 nTPM
Liver	44.0 nTPM
Testis	42.7 nTPM
Skin	40.2 nTPM
Prostate	35.7 nTPM
Ovary	34.9 nTPM
Skeletal muscle	33.2 nTPM
Endometrium	33.0 nTPM
Heart muscle	29.9 nTPM
Pancreas	23.1 nTPM
Eye	21.0 nTPM
Lung	9.3 nTPM

Fibroblasts	30.4 nTPM
Adipose tissue	42.1 nTPM
Ovary	40.0 nTPM
Heart muscle	39.5 nTPM
Placenta	36.2 nTPM
Breast	30.3 nTPM
Skin	27.6 nTPM
Esophagus	26.9 nTPM
Prostate	25.8 nTPM
Skeletal muscle	23.2 nTPM
Stomach	22.3 nTPM
Lung	21.2 nTPM

Intestinal goblet cells	31.1 nTPM
Small intestine	34.5 nTPM
Rectum	32.4 nTPM
Colon	26.4 nTPM

Macrophages	18.4 nTPM
Kidney	34.8 nTPM
Testis	32.6 nTPM
Breast	24.9 nTPM
Lung	22.6 nTPM
Prostate	20.7 nTPM
Ovary	20.2 nTPM
Endometrium	19.5 nTPM
Pancreas	17.8 nTPM
Esophagus	17.3 nTPM
Spleen	15.6 nTPM
Adipose tissue	15.3 nTPM
Skeletal muscle	13.9 nTPM
Bone marrow	12.5 nTPM
Stomach	8.8 nTPM
PBMC	0.0 nTPM

Paneth cells	25.8 nTPM
Rectum	37.8 nTPM
Small intestine	26.3 nTPM
Colon	13.2 nTPM

Plasma cells	18.9 nTPM
Bone marrow	24.7 nTPM
Spleen	20.2 nTPM
Stomach	19.9 nTPM
Adipose tissue	17.4 nTPM
Esophagus	12.3 nTPM

Respiratory ciliated cells	22.6 nTPM
Bronchus	27.8 nTPM
Lung	17.5 nTPM

Smooth muscle cells	54.0 nTPM
Bronchus	255.7 nTPM
Breast	44.7 nTPM
Esophagus	41.9 nTPM
Adipose tissue	38.8 nTPM
Skeletal muscle	38.3 nTPM
Skin	36.6 nTPM
Heart muscle	35.8 nTPM
Pancreas	34.5 nTPM
Prostate	27.5 nTPM
Ovary	21.0 nTPM
Endometrium	19.3 nTPM

T-cells	23.7 nTPM
PBMC	46.6 nTPM
Kidney	32.9 nTPM
Ovary	28.9 nTPM
Lung	28.8 nTPM
Skin	27.1 nTPM
Breast	25.5 nTPM
Skeletal muscle	24.4 nTPM
Liver	22.4 nTPM
Colon	22.3 nTPM
Bone marrow	22.3 nTPM
Adipose tissue	21.2 nTPM
Esophagus	19.7 nTPM
Lymph node	18.5 nTPM
Spleen	18.1 nTPM
Stomach	17.5 nTPM
Endometrium	17.2 nTPM
Prostate	9.5 nTPM

Basal keratinocytes	27.9 nTPM
Skin	27.9 nTPM

Basal prostatic cells	29.1 nTPM
Prostate	29.1 nTPM

Basal respiratory cells	44.2 nTPM
Bronchus	44.2 nTPM

Basal squamous epithelial cells	38.7 nTPM
Esophagus	38.7 nTPM

Undifferentiated cells	35.4 nTPM
Small intestine	48.1 nTPM
Rectum	35.2 nTPM
Colon	22.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC