Single cell type - NUDT14 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NUDT14
Gene descriptionⁱ Full gene name according to HGNC.	Nudix hydrolase 14
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal enterocytes, Distal tubular cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal enterocytes, Distal tubular cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

NUDT14 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 1
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
C6orf136	Chromosome 6 open reading frame 136	0.5057	45
BCL2L10	BCL2 like 10	0.4824	44
C19orf73	Chromosome 19 open reading frame 73	0.4796	22
RNF5	Ring finger protein 5	0.4657	67
FAM98C	Family with sequence similarity 98 member C	0.4643	45
TRAPPC6A	Trafficking protein particle complex 6A	0.4628	67
UPRT	Uracil phosphoribosyltransferase homolog	0.4507	24
KIF12	Kinesin family member 12	0.4462	67
PNPLA4	Patatin like phospholipase domain containing 4	0.4452	67
PNPO	Pyridoxamine 5'-phosphate oxidase	0.4415	67
SMIM20	Small integral membrane protein 20	0.4368	39
MGAT4A	Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A	0.4337	24
GLOD4	Glyoxalase domain containing 4	0.4315	39
THAP4	THAP domain containing 4	0.4302	39
ATP1B1	ATPase Na+/K+ transporting subunit beta 1	0.4300	67

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	66.1 nTPM
Breast	92.4 nTPM
Adipose tissue	39.8 nTPM

Alveolar cells type 1	12.8 nTPM
Lung	12.8 nTPM

Alveolar cells type 2	28.5 nTPM
Lung	28.5 nTPM

Astrocytes	5.2 nTPM
Brain	5.2 nTPM

B-cells	12.4 nTPM
Kidney	23.8 nTPM
Colon	14.4 nTPM
Stomach	14.1 nTPM
Spleen	13.5 nTPM
Bone marrow	13.1 nTPM
Breast	10.7 nTPM
Lymph node	10.6 nTPM
Liver	9.6 nTPM
PBMC	8.5 nTPM
Adipose tissue	6.0 nTPM

Dendritic cells	16.1 nTPM
Breast	30.6 nTPM
Adipose tissue	13.7 nTPM
PBMC	4.0 nTPM

Endothelial cells	61.6 nTPM
Testis	112.0 nTPM
Pancreas	108.1 nTPM
Placenta	93.8 nTPM
Skin	87.3 nTPM
Ovary	79.0 nTPM
Esophagus	65.2 nTPM
Heart muscle	64.2 nTPM
Breast	61.8 nTPM
Prostate	50.2 nTPM
Skeletal muscle	39.7 nTPM
Endometrium	38.7 nTPM
Eye	27.5 nTPM
Liver	19.2 nTPM
Lung	15.6 nTPM

Fibroblasts	14.7 nTPM
Placenta	31.8 nTPM
Stomach	23.7 nTPM
Heart muscle	21.8 nTPM
Skin	17.7 nTPM
Esophagus	17.2 nTPM
Breast	16.3 nTPM
Prostate	8.9 nTPM
Lung	7.8 nTPM
Ovary	6.9 nTPM
Adipose tissue	6.4 nTPM
Skeletal muscle	3.2 nTPM

Intestinal goblet cells	62.6 nTPM
Rectum	77.8 nTPM
Small intestine	65.6 nTPM
Colon	44.3 nTPM

Macrophages	33.9 nTPM
Breast	79.3 nTPM
Prostate	63.0 nTPM
Pancreas	56.2 nTPM
Ovary	47.0 nTPM
Kidney	46.8 nTPM
Esophagus	34.6 nTPM
Testis	31.4 nTPM
Spleen	30.0 nTPM
Endometrium	28.0 nTPM
Stomach	26.4 nTPM
Bone marrow	21.2 nTPM
Skeletal muscle	17.0 nTPM
Lung	15.0 nTPM
Adipose tissue	13.1 nTPM
PBMC	0.0 nTPM

Paneth cells	132.4 nTPM
Colon	145.0 nTPM
Small intestine	138.9 nTPM
Rectum	113.4 nTPM

Plasma cells	7.7 nTPM
Stomach	10.6 nTPM
Spleen	8.5 nTPM
Bone marrow	6.6 nTPM
Adipose tissue	6.4 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	65.7 nTPM
Bronchus	93.5 nTPM
Lung	37.9 nTPM

Smooth muscle cells	11.4 nTPM
Bronchus	32.3 nTPM
Pancreas	25.8 nTPM
Ovary	15.7 nTPM
Skin	10.5 nTPM
Prostate	9.7 nTPM
Heart muscle	9.5 nTPM
Breast	9.0 nTPM
Esophagus	4.6 nTPM
Endometrium	4.0 nTPM
Skeletal muscle	2.5 nTPM
Adipose tissue	1.4 nTPM

T-cells	26.8 nTPM
Breast	57.2 nTPM
Stomach	51.7 nTPM
Skin	43.7 nTPM
Prostate	42.6 nTPM
Colon	35.6 nTPM
Kidney	33.6 nTPM
Endometrium	33.3 nTPM
Ovary	26.7 nTPM
Esophagus	19.7 nTPM
Skeletal muscle	19.1 nTPM
Spleen	19.0 nTPM
Bone marrow	15.0 nTPM
Liver	14.8 nTPM
Adipose tissue	14.8 nTPM
Lymph node	10.6 nTPM
PBMC	10.1 nTPM
Lung	7.6 nTPM

Basal keratinocytes	38.9 nTPM
Skin	38.9 nTPM

Basal prostatic cells	101.7 nTPM
Prostate	101.7 nTPM

Basal respiratory cells	123.4 nTPM
Bronchus	123.4 nTPM

Basal squamous epithelial cells	52.9 nTPM
Esophagus	52.9 nTPM

Undifferentiated cells	75.4 nTPM
Rectum	103.1 nTPM
Small intestine	85.7 nTPM
Colon	37.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC