Single cell type - SNW1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SNW1
Gene descriptionⁱ Full gene name according to HGNC.	SNW domain containing 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Spermatocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Spermatocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

SNW1 is part of cluster 10 Non-specific - Unknown function with confidenceⁱ 0.99
482 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
HNRNPM	Heterogeneous nuclear ribonucleoprotein M	0.5640	10
WBP11	WW domain binding protein 11	0.5635	66
TPR	Translocated promoter region, nuclear basket protein	0.5438	13
DNTTIP2	Deoxynucleotidyltransferase terminal interacting protein 2	0.5333	10
SF3A3	Splicing factor 3a subunit 3	0.5300	10
EIF2S1	Eukaryotic translation initiation factor 2 subunit alpha	0.5272	10
CCNA1	Cyclin A1	0.5197	66
LLPH	LLP homolog, long-term synaptic facilitation factor	0.5194	66
DNAJC8	DnaJ heat shock protein family (Hsp40) member C8	0.5180	39
COPS2	COP9 signalosome subunit 2	0.5121	10
ASH2L	ASH2 like, histone lysine methyltransferase complex subunit	0.5083	66
PPIL4	Peptidylprolyl isomerase like 4	0.5028	22
ZNF143	Zinc finger protein 143	0.5004	66
MPHOSPH10	M-phase phosphoprotein 10	0.4975	10
GTPBP4	GTP binding protein 4	0.4971	44

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	86.5 nTPM
Adipose tissue	96.0 nTPM
Breast	77.0 nTPM

Alveolar cells type 1	93.0 nTPM
Lung	93.0 nTPM

Alveolar cells type 2	49.3 nTPM
Lung	49.3 nTPM

Astrocytes	13.1 nTPM
Brain	13.1 nTPM

B-cells	64.2 nTPM
Adipose tissue	97.3 nTPM
Kidney	76.1 nTPM
Colon	70.3 nTPM
PBMC	67.1 nTPM
Liver	65.9 nTPM
Lymph node	62.7 nTPM
Stomach	54.5 nTPM
Bone marrow	50.7 nTPM
Spleen	50.5 nTPM
Breast	46.8 nTPM

Dendritic cells	75.4 nTPM
Adipose tissue	107.0 nTPM
Breast	67.4 nTPM
PBMC	51.8 nTPM

Endothelial cells	69.9 nTPM
Pancreas	139.0 nTPM
Testis	88.0 nTPM
Heart muscle	76.3 nTPM
Eye	73.7 nTPM
Skeletal muscle	72.9 nTPM
Lung	71.7 nTPM
Prostate	70.9 nTPM
Placenta	69.9 nTPM
Endometrium	60.3 nTPM
Ovary	57.1 nTPM
Liver	56.8 nTPM
Skin	54.0 nTPM
Breast	47.4 nTPM
Esophagus	41.3 nTPM

Fibroblasts	64.9 nTPM
Lung	115.0 nTPM
Adipose tissue	93.5 nTPM
Prostate	78.5 nTPM
Placenta	73.0 nTPM
Heart muscle	59.5 nTPM
Skeletal muscle	58.7 nTPM
Ovary	53.7 nTPM
Breast	48.9 nTPM
Skin	46.7 nTPM
Stomach	46.0 nTPM
Esophagus	39.9 nTPM

Intestinal goblet cells	50.8 nTPM
Colon	72.9 nTPM
Rectum	41.3 nTPM
Small intestine	38.3 nTPM

Macrophages	70.7 nTPM
Lung	114.9 nTPM
Adipose tissue	113.5 nTPM
Testis	106.4 nTPM
Endometrium	87.5 nTPM
Ovary	79.9 nTPM
Pancreas	79.2 nTPM
Prostate	69.9 nTPM
Breast	66.5 nTPM
Kidney	64.3 nTPM
PBMC	54.6 nTPM
Skeletal muscle	54.0 nTPM
Spleen	50.8 nTPM
Stomach	46.9 nTPM
Bone marrow	45.0 nTPM
Esophagus	26.8 nTPM

Paneth cells	43.8 nTPM
Rectum	49.7 nTPM
Small intestine	48.8 nTPM
Colon	32.9 nTPM

Plasma cells	46.3 nTPM
Adipose tissue	60.7 nTPM
Stomach	50.3 nTPM
Spleen	45.4 nTPM
Bone marrow	44.5 nTPM
Esophagus	30.7 nTPM

Respiratory ciliated cells	88.1 nTPM
Lung	119.5 nTPM
Bronchus	56.7 nTPM

Smooth muscle cells	89.5 nTPM
Bronchus	288.7 nTPM
Pancreas	91.0 nTPM
Adipose tissue	85.2 nTPM
Heart muscle	78.6 nTPM
Prostate	78.2 nTPM
Endometrium	74.1 nTPM
Ovary	72.5 nTPM
Breast	60.8 nTPM
Skeletal muscle	59.5 nTPM
Skin	53.7 nTPM
Esophagus	41.9 nTPM

T-cells	76.8 nTPM
Adipose tissue	124.3 nTPM
Ovary	120.1 nTPM
Lung	113.9 nTPM
Prostate	94.7 nTPM
Kidney	91.1 nTPM
Endometrium	84.2 nTPM
Colon	80.3 nTPM
PBMC	78.9 nTPM
Breast	71.5 nTPM
Skin	71.3 nTPM
Liver	70.5 nTPM
Spleen	61.6 nTPM
Lymph node	60.8 nTPM
Stomach	60.3 nTPM
Skeletal muscle	55.5 nTPM
Bone marrow	54.0 nTPM
Esophagus	13.1 nTPM

Basal keratinocytes	56.5 nTPM
Skin	56.5 nTPM

Basal prostatic cells	80.4 nTPM
Prostate	80.4 nTPM

Basal respiratory cells	89.1 nTPM
Bronchus	89.1 nTPM

Basal squamous epithelial cells	33.6 nTPM
Esophagus	33.6 nTPM

Undifferentiated cells	47.9 nTPM
Colon	51.6 nTPM
Small intestine	50.5 nTPM
Rectum	41.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC