Single cell type - AP1M1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	AP1M1
Gene descriptionⁱ Full gene name according to HGNC.	Adaptor related protein complex 1 subunit mu 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

AP1M1 is part of cluster 31 Spermatids - Spermatogenesis with confidenceⁱ 1
413 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
LYRM7	LYR motif containing 7	0.5537	66
STARD6	StAR related lipid transfer domain containing 6	0.5405	31
CBARP	CACN subunit beta associated regulatory protein	0.5172	66
C8orf48	Chromosome 8 open reading frame 48	0.5060	31
FAAP24	FA core complex associated protein 24	0.4997	12
OBSL1	Obscurin like cytoskeletal adaptor 1	0.4861	31
NAIF1	Nuclear apoptosis inducing factor 1	0.4827	66
LRIT1	Leucine rich repeat, Ig-like and transmembrane domains 1	0.4802	56
ZNF879	Zinc finger protein 879	0.4770	66
MAD1L1	Mitotic arrest deficient 1 like 1	0.4594	31
HIRIP3	HIRA interacting protein 3	0.4588	12
LASP1	LIM and SH3 protein 1	0.4564	25
ZIC4	Zic family member 4	0.4536	31
ZNF688	Zinc finger protein 688	0.4521	31
NOSIP	Nitric oxide synthase interacting protein	0.4469	63

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	17.4 nTPM
Adipose tissue	18.0 nTPM
Breast	16.8 nTPM

Alveolar cells type 1	41.7 nTPM
Lung	41.7 nTPM

Alveolar cells type 2	31.2 nTPM
Lung	31.2 nTPM

Astrocytes	12.7 nTPM
Brain	12.7 nTPM

B-cells	30.6 nTPM
PBMC	47.1 nTPM
Kidney	38.1 nTPM
Stomach	35.9 nTPM
Colon	35.1 nTPM
Bone marrow	35.1 nTPM
Liver	31.6 nTPM
Spleen	27.3 nTPM
Lymph node	21.1 nTPM
Adipose tissue	19.1 nTPM
Breast	16.0 nTPM

Dendritic cells	30.5 nTPM
PBMC	35.8 nTPM
Adipose tissue	28.4 nTPM
Breast	27.4 nTPM

Endothelial cells	22.7 nTPM
Pancreas	42.5 nTPM
Placenta	27.8 nTPM
Skeletal muscle	27.8 nTPM
Ovary	25.6 nTPM
Lung	24.9 nTPM
Liver	22.9 nTPM
Eye	22.7 nTPM
Testis	21.4 nTPM
Breast	20.7 nTPM
Endometrium	20.2 nTPM
Esophagus	18.0 nTPM
Prostate	16.4 nTPM
Heart muscle	15.7 nTPM
Skin	11.2 nTPM

Fibroblasts	28.1 nTPM
Placenta	39.1 nTPM
Stomach	35.6 nTPM
Esophagus	35.1 nTPM
Skeletal muscle	33.7 nTPM
Lung	33.5 nTPM
Adipose tissue	32.1 nTPM
Ovary	25.3 nTPM
Breast	24.1 nTPM
Heart muscle	22.9 nTPM
Skin	15.2 nTPM
Prostate	12.4 nTPM

Intestinal goblet cells	7.3 nTPM
Colon	10.7 nTPM
Small intestine	7.6 nTPM
Rectum	3.7 nTPM

Macrophages	30.2 nTPM
Stomach	55.7 nTPM
Bone marrow	53.7 nTPM
Lung	44.2 nTPM
Kidney	43.2 nTPM
Skeletal muscle	34.4 nTPM
Testis	34.3 nTPM
Pancreas	33.2 nTPM
Spleen	32.1 nTPM
Adipose tissue	29.4 nTPM
Endometrium	22.5 nTPM
Ovary	20.8 nTPM
Esophagus	20.4 nTPM
Breast	17.9 nTPM
Prostate	11.5 nTPM
PBMC	0.0 nTPM

Paneth cells	5.9 nTPM
Rectum	7.6 nTPM
Colon	6.5 nTPM
Small intestine	3.7 nTPM

Plasma cells	24.5 nTPM
Bone marrow	37.9 nTPM
Spleen	33.4 nTPM
Adipose tissue	22.5 nTPM
Stomach	16.3 nTPM
Esophagus	12.3 nTPM

Respiratory ciliated cells	13.9 nTPM
Lung	20.4 nTPM
Bronchus	7.5 nTPM

Smooth muscle cells	22.8 nTPM
Pancreas	48.2 nTPM
Esophagus	34.1 nTPM
Heart muscle	27.9 nTPM
Skeletal muscle	26.5 nTPM
Endometrium	24.2 nTPM
Adipose tissue	20.3 nTPM
Ovary	20.1 nTPM
Breast	19.9 nTPM
Skin	13.3 nTPM
Prostate	12.9 nTPM
Bronchus	3.7 nTPM

T-cells	32.9 nTPM
Lung	53.2 nTPM
Bone marrow	52.4 nTPM
PBMC	51.1 nTPM
Liver	45.3 nTPM
Spleen	44.0 nTPM
Stomach	41.7 nTPM
Kidney	39.1 nTPM
Skeletal muscle	34.5 nTPM
Colon	33.7 nTPM
Lymph node	31.5 nTPM
Ovary	24.5 nTPM
Adipose tissue	24.1 nTPM
Endometrium	22.3 nTPM
Breast	20.7 nTPM
Skin	14.3 nTPM
Prostate	14.2 nTPM
Esophagus	13.1 nTPM

Basal keratinocytes	4.6 nTPM
Skin	4.6 nTPM

Basal prostatic cells	7.4 nTPM
Prostate	7.4 nTPM

Basal respiratory cells	13.2 nTPM
Bronchus	13.2 nTPM

Basal squamous epithelial cells	11.4 nTPM
Esophagus	11.4 nTPM

Undifferentiated cells	9.0 nTPM
Small intestine	13.6 nTPM
Rectum	7.5 nTPM
Colon	6.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC