Single cell type - CLDND1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CLDND1
Gene descriptionⁱ Full gene name according to HGNC.	Claudin domain containing 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	25

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CLDND1 is part of cluster 59 Non-specific - Transcription with confidenceⁱ 1
354 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
C1orf52	Chromosome 1 open reading frame 52	0.5530	28
YWHAQ	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta	0.5484	10
CGGBP1	CGG triplet repeat binding protein 1	0.5319	59
FGFR1OP2	FGFR1 oncogene partner 2	0.4973	6
TRAF6	TNF receptor associated factor 6	0.4971	59
WDR33	WD repeat domain 33	0.4891	55
VRK2	VRK serine/threonine kinase 2	0.4830	42
PPP6C	Protein phosphatase 6 catalytic subunit	0.4537	59
JMJD6	Jumonji domain containing 6, arginine demethylase and lysine hydroxylase	0.4509	7
MORF4L1	Mortality factor 4 like 1	0.4327	66
UBA2	Ubiquitin like modifier activating enzyme 2	0.4305	48
SUMO1	Small ubiquitin like modifier 1	0.4305	10
ATP8A1	ATPase phospholipid transporting 8A1	0.4283	42
NXT1	Nuclear transport factor 2 like export factor 1	0.4243	28
CDK17	Cyclin dependent kinase 17	0.4241	59

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	83.3 nTPM
Adipose tissue	87.8 nTPM
Breast	78.8 nTPM

Alveolar cells type 1	35.3 nTPM
Lung	35.3 nTPM

Alveolar cells type 2	36.6 nTPM
Lung	36.6 nTPM

Astrocytes	17.9 nTPM
Brain	17.9 nTPM

B-cells	72.1 nTPM
Lymph node	127.0 nTPM
Adipose tissue	105.2 nTPM
Spleen	94.5 nTPM
Stomach	85.8 nTPM
Breast	81.7 nTPM
Colon	73.5 nTPM
Bone marrow	56.4 nTPM
Liver	39.3 nTPM
Kidney	33.4 nTPM
PBMC	24.3 nTPM

Dendritic cells	72.8 nTPM
Adipose tissue	123.9 nTPM
Breast	82.4 nTPM
PBMC	12.0 nTPM

Endothelial cells	70.8 nTPM
Prostate	140.5 nTPM
Skin	108.7 nTPM
Liver	95.4 nTPM
Esophagus	90.5 nTPM
Heart muscle	82.2 nTPM
Breast	80.3 nTPM
Skeletal muscle	61.4 nTPM
Placenta	52.3 nTPM
Testis	52.1 nTPM
Eye	51.8 nTPM
Ovary	50.7 nTPM
Endometrium	45.4 nTPM
Pancreas	42.5 nTPM
Lung	37.4 nTPM

Fibroblasts	86.6 nTPM
Prostate	195.7 nTPM
Stomach	108.4 nTPM
Heart muscle	106.1 nTPM
Skin	95.4 nTPM
Esophagus	87.9 nTPM
Adipose tissue	86.5 nTPM
Breast	79.3 nTPM
Placenta	71.9 nTPM
Skeletal muscle	49.3 nTPM
Lung	44.6 nTPM
Ovary	27.3 nTPM

Intestinal goblet cells	19.6 nTPM
Rectum	21.4 nTPM
Small intestine	20.2 nTPM
Colon	17.2 nTPM

Macrophages	46.9 nTPM
Adipose tissue	90.5 nTPM
Esophagus	69.3 nTPM
Spleen	67.4 nTPM
Prostate	64.2 nTPM
Breast	55.3 nTPM
Pancreas	43.4 nTPM
Endometrium	41.7 nTPM
Stomach	41.0 nTPM
Skeletal muscle	40.0 nTPM
Testis	38.9 nTPM
Kidney	35.6 nTPM
Bone marrow	30.0 nTPM
Lung	29.7 nTPM
Ovary	29.5 nTPM
PBMC	27.3 nTPM

Paneth cells	16.8 nTPM
Rectum	26.0 nTPM
Colon	13.2 nTPM
Small intestine	11.3 nTPM

Plasma cells	131.7 nTPM
Stomach	186.8 nTPM
Esophagus	160.2 nTPM
Spleen	145.1 nTPM
Adipose tissue	89.0 nTPM
Bone marrow	77.4 nTPM

Respiratory ciliated cells	27.5 nTPM
Bronchus	37.4 nTPM
Lung	17.5 nTPM

Smooth muscle cells	128.4 nTPM
Bronchus	425.1 nTPM
Heart muscle	177.5 nTPM
Prostate	145.6 nTPM
Esophagus	141.1 nTPM
Skin	113.4 nTPM
Breast	94.5 nTPM
Adipose tissue	88.5 nTPM
Skeletal muscle	70.0 nTPM
Ovary	67.8 nTPM
Pancreas	45.9 nTPM
Endometrium	42.6 nTPM

T-cells	147.1 nTPM
Skin	309.9 nTPM
Colon	271.3 nTPM
Lymph node	259.8 nTPM
Spleen	205.7 nTPM
Esophagus	196.5 nTPM
Adipose tissue	154.4 nTPM
Stomach	153.3 nTPM
Breast	123.7 nTPM
Prostate	123.0 nTPM
Bone marrow	112.3 nTPM
Lung	109.4 nTPM
Endometrium	102.1 nTPM
Liver	86.4 nTPM
Kidney	86.2 nTPM
Ovary	82.3 nTPM
Skeletal muscle	68.4 nTPM
PBMC	55.8 nTPM

Basal keratinocytes	144.0 nTPM
Skin	144.0 nTPM

Basal respiratory cells	122.3 nTPM
Bronchus	122.3 nTPM

Basal squamous epithelial cells	87.0 nTPM
Esophagus	87.0 nTPM

Collecting duct cells	27.6 nTPM
Kidney	27.6 nTPM

Undifferentiated cells	17.5 nTPM
Rectum	20.3 nTPM
Small intestine	18.2 nTPM
Colon	14.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC