Single cell type - FAT1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FAT1
Gene descriptionⁱ Full gene name according to HGNC.	FAT atypical cadherin 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Granulosa cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Basal respiratory cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected in immune cells
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Not detected
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (fHDF/TERT166, LHCN-M2)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Basal respiratory cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

FAT1 is part of cluster 40 Granulosa cells - Unknown function with confidenceⁱ 1
316 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
BMP3	Bone morphogenetic protein 3	0.5417	40
PAK5	P21 (RAC1) activated kinase 5	0.5356	40
YAP1	Yes1 associated transcriptional regulator	0.5267	40
TMEM272	Transmembrane protein 272	0.5231	40
CES3	Carboxylesterase 3	0.5167	53
CDH3	Cadherin 3	0.5048	26
GPR21	G protein-coupled receptor 21	0.5047	48
ADCY6	Adenylate cyclase 6	0.5043	53
IFNE	Interferon epsilon	0.5025	22
SOX4	SRY-box transcription factor 4	0.4993	40
CASP6	Caspase 6	0.4733	40
ALDH18A1	Aldehyde dehydrogenase 18 family member A1	0.4731	40
ITGB5	Integrin subunit beta 5	0.4710	40
MARVELD1	MARVEL domain containing 1	0.4684	40
AMTN	Amelotin	0.4684	26

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	6.1 nTPM
Breast	9.9 nTPM
Adipose tissue	2.4 nTPM

Alveolar cells type 1	16.0 nTPM
Lung	16.0 nTPM

Alveolar cells type 2	6.7 nTPM
Lung	6.7 nTPM

Astrocytes	55.2 nTPM
Brain	55.2 nTPM

B-cells	0.3 nTPM
Breast	1.3 nTPM
Liver	0.9 nTPM
Stomach	0.5 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Dendritic cells	0.2 nTPM
Breast	0.7 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM

Endothelial cells	5.0 nTPM
Eye	13.7 nTPM
Placenta	11.3 nTPM
Skin	9.6 nTPM
Breast	9.4 nTPM
Prostate	6.4 nTPM
Lung	6.2 nTPM
Heart muscle	5.0 nTPM
Endometrium	3.5 nTPM
Skeletal muscle	1.7 nTPM
Ovary	1.7 nTPM
Testis	1.1 nTPM
Esophagus	0.6 nTPM
Liver	0.0 nTPM
Pancreas	0.0 nTPM

Fibroblasts	28.8 nTPM
Lung	70.4 nTPM
Skeletal muscle	41.3 nTPM
Heart muscle	40.4 nTPM
Skin	30.9 nTPM
Ovary	25.6 nTPM
Prostate	25.3 nTPM
Adipose tissue	24.0 nTPM
Stomach	22.3 nTPM
Breast	16.6 nTPM
Esophagus	11.3 nTPM
Placenta	8.7 nTPM

Intestinal goblet cells	56.4 nTPM
Rectum	65.1 nTPM
Colon	57.9 nTPM
Small intestine	46.2 nTPM

Macrophages	1.7 nTPM
Kidney	4.6 nTPM
Endometrium	4.1 nTPM
Lung	3.5 nTPM
Stomach	2.9 nTPM
Skeletal muscle	2.3 nTPM
Prostate	2.2 nTPM
Esophagus	1.6 nTPM
Ovary	1.5 nTPM
Testis	1.2 nTPM
Breast	0.9 nTPM
Adipose tissue	0.1 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Paneth cells	30.0 nTPM
Rectum	44.9 nTPM
Colon	26.4 nTPM
Small intestine	18.8 nTPM

Plasma cells	0.2 nTPM
Stomach	0.9 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Respiratory ciliated cells	37.0 nTPM
Bronchus	56.5 nTPM
Lung	17.5 nTPM

Smooth muscle cells	65.1 nTPM
Endometrium	149.3 nTPM
Adipose tissue	96.9 nTPM
Ovary	76.5 nTPM
Heart muscle	69.3 nTPM
Skin	68.0 nTPM
Bronchus	58.7 nTPM
Breast	50.9 nTPM
Skeletal muscle	41.2 nTPM
Esophagus	40.3 nTPM
Pancreas	34.8 nTPM
Prostate	29.7 nTPM

T-cells	1.9 nTPM
Kidney	6.9 nTPM
Esophagus	6.6 nTPM
Skin	4.6 nTPM
Endometrium	4.6 nTPM
Ovary	4.5 nTPM
Colon	3.3 nTPM
Skeletal muscle	1.5 nTPM
Breast	0.7 nTPM
Stomach	0.3 nTPM
Liver	0.0 nTPM
Lung	0.0 nTPM
Prostate	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Basal keratinocytes	85.0 nTPM
Skin	85.0 nTPM

Basal prostatic cells	27.2 nTPM
Prostate	27.2 nTPM

Basal squamous epithelial cells	27.3 nTPM
Esophagus	27.3 nTPM

Cholangiocytes	38.6 nTPM
Liver	38.6 nTPM

Undifferentiated cells	45.1 nTPM
Colon	55.7 nTPM
Rectum	48.8 nTPM
Small intestine	30.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC