Single cell type - SPATS2L - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SPATS2L
Gene descriptionⁱ Full gene name according to HGNC.	Spermatogenesis associated serine rich 2 like
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	21

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Intestinal epithelial cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal tubular cells, Distal enterocytes, Skeletal myocytes, Paneth cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (basophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (RPTEC TERT1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal tubular cells, Distal enterocytes, Skeletal myocytes, Paneth cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

SPATS2L is part of cluster 53 Intestinal epithelial cells - Unknown function with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CEACAM1	CEA cell adhesion molecule 1	0.6974	53
TRIM31	Tripartite motif containing 31	0.6643	53
KRTAP13-2	Keratin associated protein 13-2	0.6575	53
CHMP2B	Charged multivesicular body protein 2B	0.6533	53
CLCA4	Chloride channel accessory 4	0.6502	53
MYO15B	Myosin XVB	0.6446	53
TMPRSS2	Transmembrane serine protease 2	0.6382	53
SGK2	Serum/glucocorticoid regulated kinase 2	0.6369	53
CFDP1	Craniofacial development protein 1	0.6314	53
OAS1	2'-5'-oligoadenylate synthetase 1	0.6272	53
PDZD3	PDZ domain containing 3	0.6265	53
TMCC3	Transmembrane and coiled-coil domain family 3	0.6237	53
CD177	CD177 molecule	0.6222	53
CEACAM7	CEA cell adhesion molecule 7	0.6222	53
ABHD3	Abhydrolase domain containing 3, phospholipase	0.6213	53

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	83.4 nTPM
Breast	83.6 nTPM
Adipose tissue	83.1 nTPM

Alveolar cells type 1	86.6 nTPM
Lung	86.6 nTPM

Alveolar cells type 2	26.2 nTPM
Lung	26.2 nTPM

Astrocytes	104.5 nTPM
Brain	104.5 nTPM

B-cells	11.2 nTPM
Kidney	42.9 nTPM
Breast	20.0 nTPM
Colon	19.2 nTPM
Liver	13.9 nTPM
Spleen	5.5 nTPM
Stomach	4.1 nTPM
Adipose tissue	4.0 nTPM
Lymph node	2.5 nTPM
PBMC	0.0 nTPM
Bone marrow	0.0 nTPM

Dendritic cells	9.5 nTPM
Breast	13.9 nTPM
Adipose tissue	10.6 nTPM
PBMC	4.0 nTPM

Endothelial cells	64.2 nTPM
Liver	100.9 nTPM
Breast	91.3 nTPM
Eye	87.4 nTPM
Skeletal muscle	85.6 nTPM
Skin	84.3 nTPM
Prostate	76.2 nTPM
Ovary	63.6 nTPM
Heart muscle	56.3 nTPM
Testis	52.1 nTPM
Pancreas	50.2 nTPM
Placenta	47.2 nTPM
Endometrium	37.9 nTPM
Lung	34.3 nTPM
Esophagus	32.0 nTPM

Fibroblasts	101.8 nTPM
Prostate	218.2 nTPM
Skin	144.8 nTPM
Breast	139.9 nTPM
Placenta	119.6 nTPM
Lung	102.7 nTPM
Adipose tissue	97.3 nTPM
Heart muscle	91.1 nTPM
Skeletal muscle	82.3 nTPM
Ovary	49.4 nTPM
Stomach	40.1 nTPM
Esophagus	34.5 nTPM

Intestinal goblet cells	246.6 nTPM
Colon	339.4 nTPM
Small intestine	217.8 nTPM
Rectum	182.6 nTPM

Macrophages	56.1 nTPM
Ovary	130.2 nTPM
Prostate	118.1 nTPM
Lung	78.0 nTPM
Kidney	68.8 nTPM
Adipose tissue	64.5 nTPM
Endometrium	61.2 nTPM
Testis	56.4 nTPM
Skeletal muscle	53.5 nTPM
Breast	51.4 nTPM
Spleen	44.6 nTPM
Esophagus	40.9 nTPM
Pancreas	38.3 nTPM
Bone marrow	13.8 nTPM
PBMC	13.6 nTPM
Stomach	8.8 nTPM

Paneth cells	467.4 nTPM
Colon	1054.0 nTPM
Small intestine	176.5 nTPM
Rectum	171.9 nTPM

Plasma cells	9.4 nTPM
Adipose tissue	25.2 nTPM
Stomach	6.4 nTPM
Esophagus	6.1 nTPM
Bone marrow	5.0 nTPM
Spleen	4.2 nTPM

Respiratory ciliated cells	167.1 nTPM
Bronchus	175.5 nTPM
Lung	158.9 nTPM

Smooth muscle cells	89.3 nTPM
Adipose tissue	139.0 nTPM
Prostate	125.3 nTPM
Pancreas	112.5 nTPM
Endometrium	111.9 nTPM
Skin	101.3 nTPM
Skeletal muscle	89.3 nTPM
Breast	81.8 nTPM
Ovary	74.9 nTPM
Heart muscle	67.7 nTPM
Esophagus	43.4 nTPM
Bronchus	35.5 nTPM

T-cells	28.2 nTPM
Prostate	104.2 nTPM
Kidney	47.2 nTPM
Skin	39.6 nTPM
Adipose tissue	35.6 nTPM
Skeletal muscle	32.6 nTPM
Endometrium	32.2 nTPM
Colon	29.0 nTPM
Breast	26.3 nTPM
Liver	24.3 nTPM
Esophagus	19.7 nTPM
Ovary	17.8 nTPM
Lung	16.7 nTPM
Spleen	12.5 nTPM
Bone marrow	12.2 nTPM
Stomach	11.7 nTPM
PBMC	11.2 nTPM
Lymph node	6.8 nTPM

Basal prostatic cells	262.5 nTPM
Prostate	262.5 nTPM

Basal respiratory cells	123.6 nTPM
Bronchus	123.6 nTPM

Cholangiocytes	403.2 nTPM
Liver	403.2 nTPM

Collecting duct cells	172.9 nTPM
Kidney	172.9 nTPM

Undifferentiated cells	78.4 nTPM
Colon	99.8 nTPM
Rectum	70.7 nTPM
Small intestine	64.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC