Single cell type - RGS1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RGS1
Gene descriptionⁱ Full gene name according to HGNC.	Regulator of G protein signaling 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Macrophages - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (granulocytes, Langerhans cells, Plasma cells, Macrophages, T-cells, Hofbauer cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (eosinophil, T-reg)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enriched (U-266/70)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (granulocytes, Langerhans cells, Plasma cells, Macrophages, T-cells, Hofbauer cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

RGS1 is part of cluster 41 Macrophages - Immune response with confidenceⁱ 1
307 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
KLHL6	Kelch like family member 6	0.6991	41
RGS2	Regulator of G protein signaling 2	0.6800	60
ERN1	Endoplasmic reticulum to nucleus signaling 1	0.6230	55
IL10	Interleukin 10	0.6180	41
SRGN	Serglycin	0.6168	41
CD200R1	CD200 receptor 1	0.5934	4
IFNB1	Interferon beta 1	0.5930	41
ASCL4	Achaete-scute family bHLH transcription factor 4	0.5820	41
ANKRD28	Ankyrin repeat domain 28	0.5804	55
CCL3	C-C motif chemokine ligand 3	0.5759	4
CD84	CD84 molecule	0.5741	4
BCAS2	BCAS2 pre-mRNA processing factor	0.5738	7
CLEC10A	C-type lectin domain containing 10A	0.5704	41
FCGR2A	Fc fragment of IgG receptor IIa	0.5632	4
ZNF267	Zinc finger protein 267	0.5624	41

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	10.8 nTPM
Breast	19.0 nTPM
Adipose tissue	2.6 nTPM

Alveolar cells type 1	12.8 nTPM
Lung	12.8 nTPM

Alveolar cells type 2	103.2 nTPM
Lung	103.2 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	170.6 nTPM
Stomach	627.6 nTPM
Colon	330.7 nTPM
Adipose tissue	224.6 nTPM
Liver	183.8 nTPM
Breast	131.1 nTPM
Lymph node	89.1 nTPM
Spleen	86.5 nTPM
Kidney	23.8 nTPM
Bone marrow	9.0 nTPM
PBMC	0.0 nTPM

Dendritic cells	148.8 nTPM
Adipose tissue	333.1 nTPM
Breast	93.3 nTPM
PBMC	20.0 nTPM

Endothelial cells	32.7 nTPM
Eye	351.1 nTPM
Skin	35.0 nTPM
Lung	24.9 nTPM
Esophagus	12.9 nTPM
Breast	11.9 nTPM
Liver	8.2 nTPM
Prostate	3.3 nTPM
Placenta	2.9 nTPM
Endometrium	2.7 nTPM
Skeletal muscle	2.0 nTPM
Testis	1.4 nTPM
Heart muscle	0.9 nTPM
Pancreas	0.0 nTPM
Ovary	0.0 nTPM

Fibroblasts	15.4 nTPM
Stomach	55.0 nTPM
Lung	39.1 nTPM
Skin	30.9 nTPM
Prostate	14.6 nTPM
Breast	12.6 nTPM
Placenta	5.8 nTPM
Esophagus	3.6 nTPM
Heart muscle	3.4 nTPM
Adipose tissue	2.8 nTPM
Skeletal muscle	2.0 nTPM
Ovary	0.0 nTPM

Intestinal goblet cells	1.6 nTPM
Colon	3.6 nTPM
Rectum	0.9 nTPM
Small intestine	0.4 nTPM

Macrophages	860.4 nTPM
Prostate	3612.1 nTPM
Testis	2446.3 nTPM
Adipose tissue	1587.7 nTPM
Breast	1282.3 nTPM
Endometrium	1070.1 nTPM
Esophagus	980.4 nTPM
Ovary	560.7 nTPM
Lung	272.7 nTPM
Stomach	266.7 nTPM
Skeletal muscle	257.0 nTPM
Pancreas	227.2 nTPM
Spleen	201.2 nTPM
Kidney	110.4 nTPM
Bone marrow	31.2 nTPM
PBMC	0.0 nTPM

Paneth cells	3.5 nTPM
Colon	6.5 nTPM
Small intestine	3.7 nTPM
Rectum	0.4 nTPM

Plasma cells	902.4 nTPM
Stomach	2358.8 nTPM
Esophagus	1145.6 nTPM
Adipose tissue	723.8 nTPM
Spleen	206.2 nTPM
Bone marrow	77.4 nTPM

Respiratory ciliated cells	11.3 nTPM
Lung	20.4 nTPM
Bronchus	2.2 nTPM

Smooth muscle cells	8.5 nTPM
Breast	24.5 nTPM
Skin	24.1 nTPM
Esophagus	23.3 nTPM
Prostate	11.0 nTPM
Skeletal muscle	3.9 nTPM
Endometrium	2.8 nTPM
Heart muscle	1.8 nTPM
Pancreas	1.5 nTPM
Adipose tissue	0.9 nTPM
Ovary	0.1 nTPM
Bronchus	0.0 nTPM

T-cells	748.2 nTPM
Prostate	5169.4 nTPM
Adipose tissue	1119.1 nTPM
Stomach	1116.0 nTPM
Skin	804.9 nTPM
Colon	730.8 nTPM
Breast	660.1 nTPM
Ovary	484.9 nTPM
Endometrium	426.0 nTPM
Lung	382.7 nTPM
Spleen	357.6 nTPM
Liver	309.1 nTPM
Esophagus	307.9 nTPM
Bone marrow	256.8 nTPM
Skeletal muscle	226.9 nTPM
Lymph node	204.1 nTPM
Kidney	156.7 nTPM
PBMC	5.8 nTPM

Basal keratinocytes	49.2 nTPM
Skin	49.2 nTPM

Basal prostatic cells	6.9 nTPM
Prostate	6.9 nTPM

Basal respiratory cells	0.3 nTPM
Bronchus	0.3 nTPM

Basal squamous epithelial cells	5.7 nTPM
Esophagus	5.7 nTPM

Undifferentiated cells	4.0 nTPM
Colon	11.4 nTPM
Rectum	0.5 nTPM
Small intestine	0.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC