Single cell type - DHRS7B - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DHRS7B
Gene descriptionⁱ Full gene name according to HGNC.	Dehydrogenase/reductase 7B
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatocytes - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

DHRS7B is part of cluster 66 Spermatocytes - Spermatogenesis with confidenceⁱ 0.5
507 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CRYZL1	Crystallin zeta like 1	0.5419	66
RNF121	Ring finger protein 121	0.5410	55
RARS2	Arginyl-tRNA synthetase 2, mitochondrial	0.5270	66
ANAPC10	Anaphase promoting complex subunit 10	0.5203	66
EMC2	ER membrane protein complex subunit 2	0.5134	26
TEX264	Testis expressed 264, ER-phagy receptor	0.4912	13
FDFT1	Farnesyl-diphosphate farnesyltransferase 1	0.4858	26
UNC50	Unc-50 inner nuclear membrane RNA binding protein	0.4842	26
BTD	Biotinidase	0.4841	66
SEC22A	SEC22 homolog A, vesicle trafficking protein	0.4653	66
PLRG1	Pleiotropic regulator 1	0.4569	26
AMN1	Antagonist of mitotic exit network 1 homolog	0.4550	66
NDUFAF1	NADH:ubiquinone oxidoreductase complex assembly factor 1	0.4452	66
ARRDC1	Arrestin domain containing 1	0.4431	26
KBTBD3	Kelch repeat and BTB domain containing 3	0.4395	66

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	31.1 nTPM
Breast	34.1 nTPM
Adipose tissue	28.1 nTPM

Alveolar cells type 1	16.0 nTPM
Lung	16.0 nTPM

Alveolar cells type 2	18.1 nTPM
Lung	18.1 nTPM

Astrocytes	29.4 nTPM
Brain	29.4 nTPM

B-cells	11.9 nTPM
PBMC	22.8 nTPM
Liver	21.7 nTPM
Colon	20.8 nTPM
Kidney	14.3 nTPM
Breast	12.1 nTPM
Bone marrow	6.6 nTPM
Adipose tissue	6.0 nTPM
Lymph node	5.9 nTPM
Spleen	5.5 nTPM
Stomach	3.7 nTPM

Dendritic cells	11.3 nTPM
PBMC	16.0 nTPM
Breast	11.7 nTPM
Adipose tissue	6.3 nTPM

Endothelial cells	23.7 nTPM
Placenta	33.5 nTPM
Ovary	30.3 nTPM
Skeletal muscle	28.9 nTPM
Eye	27.5 nTPM
Breast	27.5 nTPM
Pancreas	27.0 nTPM
Prostate	25.4 nTPM
Skin	22.5 nTPM
Testis	22.0 nTPM
Liver	21.1 nTPM
Esophagus	21.0 nTPM
Heart muscle	20.6 nTPM
Endometrium	15.5 nTPM
Lung	9.3 nTPM

Fibroblasts	18.9 nTPM
Adipose tissue	30.9 nTPM
Placenta	30.2 nTPM
Skeletal muscle	23.7 nTPM
Breast	23.3 nTPM
Skin	21.4 nTPM
Prostate	18.2 nTPM
Ovary	15.8 nTPM
Esophagus	15.1 nTPM
Stomach	11.9 nTPM
Heart muscle	11.3 nTPM
Lung	5.6 nTPM

Intestinal goblet cells	28.5 nTPM
Small intestine	36.2 nTPM
Colon	32.2 nTPM
Rectum	17.1 nTPM

Macrophages	14.3 nTPM
Ovary	28.7 nTPM
Kidney	24.2 nTPM
Bone marrow	20.0 nTPM
Breast	19.6 nTPM
Skeletal muscle	14.4 nTPM
PBMC	13.6 nTPM
Testis	12.8 nTPM
Pancreas	12.8 nTPM
Prostate	12.6 nTPM
Stomach	11.7 nTPM
Endometrium	10.9 nTPM
Lung	10.7 nTPM
Spleen	8.3 nTPM
Adipose tissue	8.1 nTPM
Esophagus	6.3 nTPM

Paneth cells	24.8 nTPM
Small intestine	30.0 nTPM
Rectum	24.7 nTPM
Colon	19.7 nTPM

Plasma cells	10.5 nTPM
Stomach	14.0 nTPM
Esophagus	12.3 nTPM
Spleen	12.3 nTPM
Bone marrow	8.2 nTPM
Adipose tissue	5.8 nTPM

Respiratory ciliated cells	50.7 nTPM
Bronchus	70.8 nTPM
Lung	30.6 nTPM

Smooth muscle cells	18.2 nTPM
Pancreas	29.7 nTPM
Bronchus	28.9 nTPM
Prostate	19.1 nTPM
Skeletal muscle	19.0 nTPM
Breast	18.9 nTPM
Heart muscle	18.3 nTPM
Ovary	16.0 nTPM
Endometrium	15.8 nTPM
Adipose tissue	12.7 nTPM
Skin	12.5 nTPM
Esophagus	9.3 nTPM

T-cells	11.2 nTPM
Prostate	28.4 nTPM
PBMC	21.9 nTPM
Kidney	21.2 nTPM
Liver	20.1 nTPM
Colon	18.1 nTPM
Breast	12.2 nTPM
Skin	11.6 nTPM
Skeletal muscle	10.0 nTPM
Endometrium	9.9 nTPM
Bone marrow	7.5 nTPM
Ovary	6.7 nTPM
Spleen	6.0 nTPM
Lung	4.5 nTPM
Lymph node	4.1 nTPM
Stomach	4.0 nTPM
Adipose tissue	3.7 nTPM
Esophagus	0.0 nTPM

Basal keratinocytes	16.3 nTPM
Skin	16.3 nTPM

Basal prostatic cells	26.7 nTPM
Prostate	26.7 nTPM

Basal respiratory cells	59.0 nTPM
Bronchus	59.0 nTPM

Basal squamous epithelial cells	11.4 nTPM
Esophagus	11.4 nTPM

Undifferentiated cells	22.2 nTPM
Small intestine	24.3 nTPM
Colon	21.9 nTPM
Rectum	20.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC