Single cell type - HBEGF - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HBEGF
Gene descriptionⁱ Full gene name according to HGNC.	Heparin binding EGF like growth factor
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Epithelial cell types - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Basal prostatic cells, Urothelial cells, Squamous epithelial cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (intermediate monocyte, non-classical monocyte, myeloid DC)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HBF TERT88, JURKAT, TIME, U-698)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Basal prostatic cells, Urothelial cells, Squamous epithelial cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

HBEGF is part of cluster 22 Epithelial cell types - Mixed function with confidenceⁱ 1
298 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
FOSL1	FOS like 1, AP-1 transcription factor subunit	0.7716	22
RAET1L	Retinoic acid early transcript 1L	0.7587	22
HCAR3	Hydroxycarboxylic acid receptor 3	0.7523	61
TNS4	Tensin 4	0.7257	61
KRTAP3-1	Keratin associated protein 3-1	0.7216	22
HSPB1	Heat shock protein family B (small) member 1	0.7208	22
MPZL2	Myelin protein zero like 2	0.7183	22
KRT17	Keratin 17	0.7144	22
RNASE7	Ribonuclease A family member 7	0.6932	22
CXCL8	C-X-C motif chemokine ligand 8	0.6859	22
KRTAP4-12	Keratin associated protein 4-12	0.6771	22
DLK2	Delta like non-canonical Notch ligand 2	0.6741	22
BARX2	BARX homeobox 2	0.6733	61
BAG3	BAG cochaperone 3	0.6695	22
TACSTD2	Tumor associated calcium signal transducer 2	0.6685	22

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	186.2 nTPM
Adipose tissue	207.0 nTPM
Breast	165.4 nTPM

Alveolar cells type 1	221.2 nTPM
Lung	221.2 nTPM

Alveolar cells type 2	69.3 nTPM
Lung	69.3 nTPM

Astrocytes	1.3 nTPM
Brain	1.3 nTPM

B-cells	5.7 nTPM
Colon	22.3 nTPM
Lymph node	10.5 nTPM
Breast	9.4 nTPM
Spleen	6.9 nTPM
Adipose tissue	4.5 nTPM
Liver	1.8 nTPM
Bone marrow	0.8 nTPM
Stomach	0.5 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM

Dendritic cells	5.4 nTPM
Breast	12.8 nTPM
Adipose tissue	3.5 nTPM
PBMC	0.0 nTPM

Endothelial cells	94.7 nTPM
Skin	283.8 nTPM
Esophagus	184.7 nTPM
Prostate	184.3 nTPM
Breast	183.9 nTPM
Skeletal muscle	109.0 nTPM
Lung	71.7 nTPM
Pancreas	69.5 nTPM
Eye	56.7 nTPM
Ovary	51.4 nTPM
Heart muscle	39.4 nTPM
Endometrium	31.4 nTPM
Placenta	29.0 nTPM
Testis	25.2 nTPM
Liver	5.5 nTPM

Enteroendocrine cells	88.3 nTPM
Colon	120.8 nTPM
Rectum	55.8 nTPM

Fibroblasts	35.2 nTPM
Lung	82.7 nTPM
Prostate	82.3 nTPM
Stomach	81.7 nTPM
Heart muscle	41.9 nTPM
Breast	26.9 nTPM
Skin	21.6 nTPM
Esophagus	21.4 nTPM
Skeletal muscle	13.4 nTPM
Adipose tissue	9.2 nTPM
Placenta	5.9 nTPM
Ovary	0.5 nTPM

Intestinal goblet cells	105.1 nTPM
Colon	203.0 nTPM
Rectum	59.6 nTPM
Small intestine	52.7 nTPM

Macrophages	210.2 nTPM
Stomach	591.9 nTPM
Lung	369.5 nTPM
Skeletal muscle	356.1 nTPM
Esophagus	350.9 nTPM
Spleen	327.6 nTPM
Adipose tissue	301.2 nTPM
Pancreas	219.5 nTPM
Ovary	139.6 nTPM
Endometrium	117.5 nTPM
Breast	101.0 nTPM
Prostate	94.0 nTPM
Kidney	93.8 nTPM
Testis	68.6 nTPM
Bone marrow	22.5 nTPM
PBMC	0.0 nTPM

Paneth cells	130.6 nTPM
Colon	266.8 nTPM
Small intestine	78.9 nTPM
Rectum	46.1 nTPM

Plasma cells	3.1 nTPM
Adipose tissue	6.4 nTPM
Esophagus	6.1 nTPM
Stomach	2.0 nTPM
Spleen	0.7 nTPM
Bone marrow	0.0 nTPM

Respiratory ciliated cells	16.4 nTPM
Lung	19.0 nTPM
Bronchus	13.9 nTPM

Smooth muscle cells	33.1 nTPM
Prostate	57.2 nTPM
Pancreas	55.7 nTPM
Breast	51.6 nTPM
Bronchus	48.4 nTPM
Esophagus	34.1 nTPM
Endometrium	30.1 nTPM
Skeletal muscle	22.3 nTPM
Skin	19.9 nTPM
Adipose tissue	18.1 nTPM
Ovary	16.9 nTPM
Heart muscle	10.0 nTPM

Basal keratinocytes	214.6 nTPM
Skin	214.6 nTPM

Basal respiratory cells	161.9 nTPM
Bronchus	161.9 nTPM

Cholangiocytes	24.3 nTPM
Liver	24.3 nTPM

Collecting duct cells	11.0 nTPM
Kidney	11.0 nTPM

T-cells	12.7 nTPM
Prostate	66.3 nTPM
Lung	28.8 nTPM
Adipose tissue	24.0 nTPM
Breast	18.0 nTPM
Endometrium	14.1 nTPM
Lymph node	13.7 nTPM
Esophagus	13.1 nTPM
Skeletal muscle	9.5 nTPM
Skin	9.2 nTPM
Colon	6.6 nTPM
Spleen	6.5 nTPM
Stomach	3.6 nTPM
Kidney	0.7 nTPM
Liver	0.7 nTPM
Bone marrow	0.6 nTPM
PBMC	0.0 nTPM
Ovary	0.0 nTPM

Undifferentiated cells	97.7 nTPM
Colon	171.9 nTPM
Small intestine	75.3 nTPM
Rectum	45.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC