Single cell type - HEATR1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HEATR1
Gene descriptionⁱ Full gene name according to HGNC.	HEAT repeat containing 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

HEATR1 is part of cluster 59 Non-specific - Transcription with confidenceⁱ 0.98
354 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
UTP20	UTP20 small subunit processome component	0.6673	59
POLR1A	RNA polymerase I subunit A	0.6305	59
TAF2	TATA-box binding protein associated factor 2	0.5902	59
PRKDC	Protein kinase, DNA-activated, catalytic subunit	0.5426	36
ABCE1	ATP binding cassette subfamily E member 1	0.5352	39
MCM3AP	Minichromosome maintenance complex component 3 associated protein	0.5351	59
GART	Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	0.5261	39
NAT10	N-acetyltransferase 10	0.5257	59
NSUN2	NOP2/Sun RNA methyltransferase 2	0.5242	59
LSG1	Large 60S subunit nuclear export GTPase 1	0.5211	60
TCERG1	Transcription elongation regulator 1	0.5186	10
ZNF770	Zinc finger protein 770	0.5154	13
PFAS	Phosphoribosylformylglycinamidine synthase	0.5124	52
NOP14	NOP14 nucleolar protein	0.5054	10
TGS1	Trimethylguanosine synthase 1	0.5004	59

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	13.3 nTPM
Adipose tissue	15.3 nTPM
Breast	11.4 nTPM

Alveolar cells type 1	3.2 nTPM
Lung	3.2 nTPM

Alveolar cells type 2	12.8 nTPM
Lung	12.8 nTPM

Astrocytes	19.6 nTPM
Brain	19.6 nTPM

B-cells	21.8 nTPM
Stomach	36.3 nTPM
Spleen	33.2 nTPM
Bone marrow	32.7 nTPM
Lymph node	28.7 nTPM
Adipose tissue	26.6 nTPM
Colon	19.2 nTPM
Breast	13.4 nTPM
Liver	11.0 nTPM
Kidney	9.5 nTPM
PBMC	7.1 nTPM

Dendritic cells	15.0 nTPM
Adipose tissue	21.6 nTPM
PBMC	12.0 nTPM
Breast	11.3 nTPM

Endothelial cells	12.4 nTPM
Endometrium	19.9 nTPM
Lung	15.6 nTPM
Skeletal muscle	14.7 nTPM
Ovary	14.7 nTPM
Esophagus	14.5 nTPM
Prostate	13.1 nTPM
Liver	11.9 nTPM
Pancreas	11.6 nTPM
Skin	11.0 nTPM
Placenta	10.8 nTPM
Breast	10.4 nTPM
Heart muscle	10.0 nTPM
Testis	9.5 nTPM
Eye	5.7 nTPM

Fibroblasts	15.2 nTPM
Lung	39.1 nTPM
Skeletal muscle	19.5 nTPM
Ovary	18.4 nTPM
Adipose tissue	15.0 nTPM
Stomach	14.9 nTPM
Prostate	12.2 nTPM
Esophagus	11.0 nTPM
Breast	11.0 nTPM
Placenta	10.6 nTPM
Skin	9.7 nTPM
Heart muscle	5.6 nTPM

Intestinal goblet cells	6.2 nTPM
Rectum	7.6 nTPM
Small intestine	6.8 nTPM
Colon	4.3 nTPM

Macrophages	11.7 nTPM
Lung	21.6 nTPM
Bone marrow	20.0 nTPM
Skeletal muscle	17.4 nTPM
Esophagus	17.3 nTPM
Endometrium	14.7 nTPM
Stomach	14.7 nTPM
Spleen	14.5 nTPM
Adipose tissue	11.9 nTPM
Testis	11.1 nTPM
Ovary	10.4 nTPM
Kidney	8.3 nTPM
Breast	7.9 nTPM
Pancreas	5.1 nTPM
Prostate	1.2 nTPM
PBMC	0.0 nTPM

Paneth cells	4.3 nTPM
Rectum	9.7 nTPM
Colon	3.3 nTPM
Small intestine	0.0 nTPM

Plasma cells	19.0 nTPM
Adipose tissue	24.5 nTPM
Spleen	23.7 nTPM
Bone marrow	19.8 nTPM
Stomach	14.8 nTPM
Esophagus	12.3 nTPM

Respiratory ciliated cells	11.5 nTPM
Lung	13.1 nTPM
Bronchus	9.9 nTPM

Smooth muscle cells	11.8 nTPM
Endometrium	18.0 nTPM
Adipose tissue	14.1 nTPM
Ovary	13.7 nTPM
Skin	13.6 nTPM
Skeletal muscle	13.2 nTPM
Prostate	12.2 nTPM
Breast	10.4 nTPM
Heart muscle	10.0 nTPM
Pancreas	9.8 nTPM
Bronchus	8.4 nTPM
Esophagus	6.2 nTPM

T-cells	18.1 nTPM
Esophagus	32.8 nTPM
Lymph node	28.3 nTPM
Adipose tissue	25.3 nTPM
Bone marrow	24.9 nTPM
Spleen	24.2 nTPM
Stomach	22.2 nTPM
Endometrium	21.3 nTPM
Lung	16.7 nTPM
Skeletal muscle	16.7 nTPM
Ovary	15.6 nTPM
PBMC	14.3 nTPM
Colon	13.8 nTPM
Skin	13.8 nTPM
Liver	11.5 nTPM
Breast	11.4 nTPM
Kidney	9.6 nTPM
Prostate	4.7 nTPM

Basal prostatic cells	16.3 nTPM
Prostate	16.3 nTPM

Basal squamous epithelial cells	26.2 nTPM
Esophagus	26.2 nTPM

Cholangiocytes	7.2 nTPM
Liver	7.2 nTPM

Collecting duct cells	5.5 nTPM
Kidney	5.5 nTPM

Undifferentiated cells	11.1 nTPM
Small intestine	11.4 nTPM
Colon	11.0 nTPM
Rectum	10.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC