Single cell type - SFXN4 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SFXN4
Gene descriptionⁱ Full gene name according to HGNC.	Sideroflexin 4
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

SFXN4 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 1
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TUFM	Tu translation elongation factor, mitochondrial	0.6166	39
ECSIT	ECSIT signaling integrator	0.5855	39
NDUFA10	NADH:ubiquinone oxidoreductase subunit A10	0.5429	39
UQCRH	Ubiquinol-cytochrome c reductase hinge protein	0.5271	39
PPA2	Inorganic pyrophosphatase 2	0.5238	39
LRPPRC	Leucine rich pentatricopeptide repeat containing	0.5201	39
UQCRC2	Ubiquinol-cytochrome c reductase core protein 2	0.5182	39
AHCY	Adenosylhomocysteinase	0.5094	67
NDUFB5	NADH:ubiquinone oxidoreductase subunit B5	0.5076	39
COQ9	Coenzyme Q9	0.5058	39
MRPL37	Mitochondrial ribosomal protein L37	0.5029	12
IDH3B	Isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta	0.4997	39
NDUFAF4	NADH:ubiquinone oxidoreductase complex assembly factor 4	0.4906	39
IMMT	Inner membrane mitochondrial protein	0.4868	39
PRDX3	Peroxiredoxin 3	0.4840	39

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	8.0 nTPM
Breast	11.5 nTPM
Adipose tissue	4.6 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	5.6 nTPM
Lung	5.6 nTPM

Astrocytes	29.0 nTPM
Brain	29.0 nTPM

B-cells	16.9 nTPM
Liver	36.3 nTPM
Breast	21.3 nTPM
Bone marrow	18.8 nTPM
PBMC	18.6 nTPM
Spleen	15.6 nTPM
Stomach	15.0 nTPM
Kidney	14.3 nTPM
Lymph node	13.4 nTPM
Adipose tissue	8.1 nTPM
Colon	8.0 nTPM

Dendritic cells	6.2 nTPM
PBMC	8.0 nTPM
Adipose tissue	5.6 nTPM
Breast	5.1 nTPM

Endothelial cells	8.4 nTPM
Placenta	14.2 nTPM
Testis	13.6 nTPM
Breast	10.6 nTPM
Prostate	10.4 nTPM
Ovary	10.1 nTPM
Endometrium	9.9 nTPM
Skin	9.3 nTPM
Esophagus	9.3 nTPM
Eye	8.1 nTPM
Heart muscle	7.5 nTPM
Skeletal muscle	5.9 nTPM
Liver	5.5 nTPM
Pancreas	3.9 nTPM
Lung	0.0 nTPM

Fibroblasts	12.4 nTPM
Heart muscle	25.3 nTPM
Placenta	15.6 nTPM
Ovary	14.9 nTPM
Prostate	12.7 nTPM
Breast	12.2 nTPM
Esophagus	11.8 nTPM
Adipose tissue	9.8 nTPM
Lung	8.9 nTPM
Stomach	8.9 nTPM
Skin	8.3 nTPM
Skeletal muscle	8.1 nTPM

Intestinal goblet cells	24.7 nTPM
Rectum	32.5 nTPM
Colon	25.0 nTPM
Small intestine	16.6 nTPM

Macrophages	13.1 nTPM
Prostate	26.3 nTPM
Ovary	22.4 nTPM
Kidney	21.9 nTPM
Bone marrow	18.8 nTPM
Pancreas	15.3 nTPM
Breast	14.7 nTPM
Spleen	14.5 nTPM
Skeletal muscle	12.3 nTPM
Testis	11.7 nTPM
Endometrium	10.9 nTPM
Adipose tissue	8.7 nTPM
Lung	8.4 nTPM
Esophagus	7.9 nTPM
Stomach	2.9 nTPM
PBMC	0.0 nTPM

Paneth cells	12.1 nTPM
Rectum	29.3 nTPM
Small intestine	3.7 nTPM
Colon	3.3 nTPM

Plasma cells	31.9 nTPM
Spleen	54.7 nTPM
Bone marrow	49.4 nTPM
Stomach	33.6 nTPM
Esophagus	12.3 nTPM
Adipose tissue	9.7 nTPM

Respiratory ciliated cells	13.5 nTPM
Bronchus	16.8 nTPM
Lung	10.2 nTPM

Smooth muscle cells	10.6 nTPM
Esophagus	18.6 nTPM
Pancreas	15.5 nTPM
Ovary	14.3 nTPM
Skin	12.2 nTPM
Breast	12.0 nTPM
Prostate	10.3 nTPM
Skeletal muscle	8.6 nTPM
Adipose tissue	8.5 nTPM
Heart muscle	6.2 nTPM
Bronchus	5.7 nTPM
Endometrium	5.0 nTPM

T-cells	9.2 nTPM
Prostate	14.2 nTPM
Lymph node	14.0 nTPM
Spleen	13.7 nTPM
Kidney	13.1 nTPM
Stomach	13.1 nTPM
Bone marrow	12.4 nTPM
PBMC	11.5 nTPM
Colon	9.5 nTPM
Liver	8.7 nTPM
Breast	8.3 nTPM
Ovary	6.7 nTPM
Esophagus	6.6 nTPM
Endometrium	6.1 nTPM
Skeletal muscle	5.9 nTPM
Skin	5.0 nTPM
Adipose tissue	4.8 nTPM
Lung	3.0 nTPM

Basal prostatic cells	25.8 nTPM
Prostate	25.8 nTPM

Basal respiratory cells	39.9 nTPM
Bronchus	39.9 nTPM

Basal squamous epithelial cells	23.3 nTPM
Esophagus	23.3 nTPM

Cholangiocytes	12.8 nTPM
Liver	12.8 nTPM

Undifferentiated cells	45.8 nTPM
Small intestine	50.9 nTPM
Rectum	48.2 nTPM
Colon	38.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC