The liver is responsible for vital biological functions in the body.

The liver is responsible for vital biological functions in the body. Abnormalities in these functions due to genetic or environmental factors, which remain only partially understood, might lead to hepatic steatosis, impaired liver function and severe hepatic disorders.

In Nature Reviews Gastroenterology & Hepatology, Adil Mardinoglu, Jan Boren, Ulf Smith, Mathias Uhlen and Jens Nielsen, give detailed insights into the biological function of the liver and an understanding of its crosstalk with other human tissues and the gut microbiota. Biological network models can provide a scaffold for studying the biological pathways operating in the liver in connection with disease development in as systematic manner.

The article also presents a roadmap for the successful integration of models of the liver and other human tissues with the gut microbiota to simulate whole-body metabolic functions in health and disease.

Read the full article here.