News ArticlesAI for Science - a new era of discoveryDuring the Nobel week Google in collaboration with KTH hosted an event on AI and science in the spectacular underground Reactor Hall at KTH...Read more RD3L - a `Gene Doe` of the heartAmong the about 20,000 genes in the human proteome there are still many rather unknown but potentially interesting proteins that deserve some extra attention. Here we will focus on RD3L, a less investigated gene related to the Retinal Degeneration Protein 3 (RD3)...Read more Multiplex tissue image of the month - BPIFB2 in salivary glandThe mucus acinus-specific expression pattern of BPI fold containing family B member 2 (gene: BPIFB2) in salivary gland is highlighted by multiplex immunohistochemistry (mIHC/IF)...Read more ERN1: A Peculiar Regulator of the Unfolded Protein ResponseThis week, we explore a fascinating protein that regulates the unfolded protein response (UPR) in eukaryotic cells in an unusual manner - by sensing the accumulation of unfolded proteins in the endoplasmic reticulum (ER) lumen and conveying this information to the nucleus. This is achieved through unconventional splicing of the XBP1 mRNA in the cytoplasm leading to the induction of a transcriptional program in the nucleus. Hence its apt name - Endoplasmic Reticulum to Nucleus Signaling, ERN1...Read more New-onset autoantibodies emerge after COVID-19 and remain for one yearA recent study published in Nature Communications has unveiled a complex landscape of autoantibodies emerging after SARS-CoV-2 infection. Researchers investigated the development of autoantibodies in a large cohort of healthcare workers and hospitalized COVID-19 patients, tracking their emergence and persistence over a 16-month period...Read more |