News Articles

Episomal stable pools in WAVE bioreactors for fast and robust protein production


Recombinant proteins are important resources in several stages of drug discovery as well as many other types of research. The amounts of pure protein required span from a few micrograms for immunisations to hundreds of milligrams or even grams for activity evaluations and structure determinations. Here a highly scalable process for protein production in CHO cells that generates robust product quality and high performance throughout scales is presented...Read more

A single cubic millimeter of human brain has generated 1,4 petabytes of data.


A publication in Science presents the largest-ever dataset of neural connections, providing a glimpse into the brain's complexity. This seemingly tiny volume of one cubic millimeter contains the impressive number of 57.000 cells, 150 million synapses, and 230 millimeter blood vessels...Read more

CD93 maintains vascular integrity and limits metastatic dissemination


Metastasis formation is a multistep process that involves cancer cell transmigration through tumor vessels and through the healthy vasculature of the affected organ. This process is limited by an intact vascular barrier formed by endothelial cells, ECM, and pericytes. In a publication in JCI Insight, researchers from HPA and Uppsala University studied the role of the protein CD93 in maintaining vascular integrity in metastatic cancers...Read more

Proteome profiling of home-sampled dried blood spots reveals proteins of SARS-CoV-2 infections


Current approaches to determine molecular signatures of health often rely on samples taken by venous blood draws at health care centers. In a study published in Communications medicine, researchers from KTH, Karolinska Institute, and the University of Gothenburg instead used a home sampling device to collect dried blood spots from the general population during the COVID-19 pandemic...Read more

Different expression patterns in invasive and noninvasive PitNETs


In a study published in the Journal of the Endocrine Society, transcriptomics analysis and radiological evaluation was used to explore the differences between invasive and noninvasive pituitary neuroendocrine tumors (PitNETs) with respect to parasellar growth, bone invasiveness and vascularization...Read more