Single cell type - EXOSC8 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EXOSC8
Gene descriptionⁱ Full gene name according to HGNC.	Exosome component 8
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatocytes - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Spermatocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Spermatocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

EXOSC8 is part of cluster 66 Spermatocytes - Spermatogenesis with confidenceⁱ 0.5
507 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
EMC2	ER membrane protein complex subunit 2	0.5046	26
DERL2	Derlin 2	0.4940	26
ARV1	ARV1 homolog, fatty acid homeostasis modulator	0.4926	66
ITGB3BP	Integrin subunit beta 3 binding protein	0.4860	12
SNRPA1	Small nuclear ribonucleoprotein polypeptide A'	0.4774	66
SNAPC1	Small nuclear RNA activating complex polypeptide 1	0.4739	26
EXOSC9	Exosome component 9	0.4717	66
BUB3	BUB3 mitotic checkpoint protein	0.4641	12
GCSAML	Germinal center associated signaling and motility like	0.4553	60
FDFT1	Farnesyl-diphosphate farnesyltransferase 1	0.4550	26
PLRG1	Pleiotropic regulator 1	0.4542	26
SVOPL	SVOP like	0.4509	60
PCNA	Proliferating cell nuclear antigen	0.4463	12
MORF4L1	Mortality factor 4 like 1	0.4458	66
CRYZL1	Crystallin zeta like 1	0.4420	66

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	43.5 nTPM
Breast	48.2 nTPM
Adipose tissue	38.9 nTPM

Alveolar cells type 1	32.1 nTPM
Lung	32.1 nTPM

Alveolar cells type 2	38.9 nTPM
Lung	38.9 nTPM

Astrocytes	15.7 nTPM
Brain	15.7 nTPM

B-cells	40.1 nTPM
PBMC	57.1 nTPM
Liver	48.6 nTPM
Spleen	41.2 nTPM
Bone marrow	40.0 nTPM
Adipose tissue	38.6 nTPM
Colon	38.3 nTPM
Kidney	38.1 nTPM
Breast	34.7 nTPM
Lymph node	32.4 nTPM
Stomach	32.2 nTPM

Dendritic cells	46.8 nTPM
Breast	66.0 nTPM
PBMC	43.8 nTPM
Adipose tissue	30.5 nTPM

Endothelial cells	39.4 nTPM
Lung	62.4 nTPM
Pancreas	61.8 nTPM
Placenta	58.5 nTPM
Heart muscle	47.4 nTPM
Skin	40.2 nTPM
Prostate	39.3 nTPM
Skeletal muscle	39.1 nTPM
Testis	34.0 nTPM
Esophagus	32.9 nTPM
Breast	32.7 nTPM
Ovary	31.6 nTPM
Endometrium	30.6 nTPM
Eye	21.0 nTPM
Liver	20.2 nTPM

Fibroblasts	41.8 nTPM
Heart muscle	68.0 nTPM
Placenta	48.3 nTPM
Adipose tissue	47.5 nTPM
Breast	47.0 nTPM
Lung	45.8 nTPM
Ovary	45.1 nTPM
Skin	35.5 nTPM
Skeletal muscle	34.2 nTPM
Stomach	29.7 nTPM
Esophagus	29.6 nTPM
Prostate	28.7 nTPM

Intestinal goblet cells	19.1 nTPM
Colon	21.5 nTPM
Rectum	18.8 nTPM
Small intestine	16.9 nTPM

Macrophages	26.0 nTPM
Lung	57.9 nTPM
Breast	44.5 nTPM
Pancreas	43.4 nTPM
Prostate	36.7 nTPM
Testis	30.8 nTPM
Kidney	28.7 nTPM
Ovary	25.2 nTPM
Adipose tissue	22.8 nTPM
Endometrium	21.9 nTPM
Skeletal muscle	18.9 nTPM
Stomach	17.6 nTPM
Bone marrow	15.0 nTPM
Esophagus	14.2 nTPM
Spleen	12.5 nTPM
PBMC	0.0 nTPM

Paneth cells	16.4 nTPM
Rectum	23.5 nTPM
Small intestine	22.5 nTPM
Colon	3.3 nTPM

Plasma cells	38.8 nTPM
Spleen	61.7 nTPM
Bone marrow	56.0 nTPM
Stomach	31.2 nTPM
Esophagus	24.6 nTPM
Adipose tissue	20.6 nTPM

Respiratory ciliated cells	53.4 nTPM
Lung	65.6 nTPM
Bronchus	41.2 nTPM

Smooth muscle cells	52.1 nTPM
Bronchus	97.4 nTPM
Pancreas	80.3 nTPM
Heart muscle	56.8 nTPM
Skeletal muscle	50.1 nTPM
Breast	47.8 nTPM
Ovary	44.9 nTPM
Adipose tissue	41.7 nTPM
Skin	41.5 nTPM
Prostate	39.7 nTPM
Esophagus	38.8 nTPM
Endometrium	34.3 nTPM

T-cells	38.7 nTPM
Lung	85.0 nTPM
Breast	58.4 nTPM
Kidney	53.4 nTPM
PBMC	47.2 nTPM
Ovary	46.7 nTPM
Skin	43.7 nTPM
Endometrium	37.0 nTPM
Liver	35.9 nTPM
Stomach	35.1 nTPM
Colon	34.7 nTPM
Lymph node	34.6 nTPM
Bone marrow	30.4 nTPM
Adipose tissue	30.0 nTPM
Spleen	29.7 nTPM
Skeletal muscle	23.4 nTPM
Prostate	19.0 nTPM
Esophagus	13.1 nTPM

Basal keratinocytes	36.1 nTPM
Skin	36.1 nTPM

Basal prostatic cells	51.6 nTPM
Prostate	51.6 nTPM

Basal respiratory cells	109.6 nTPM
Bronchus	109.6 nTPM

Basal squamous epithelial cells	25.0 nTPM
Esophagus	25.0 nTPM

Undifferentiated cells	30.2 nTPM
Small intestine	32.4 nTPM
Colon	31.6 nTPM
Rectum	26.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC