An article in PNAS describes how hypoxia and the elimination of peroxisomes drives HCC dedifferentiation, a hallmark of malignancy and a challenge for therapy. The E3 ubiquitin ligase RNF126 is identified as a hypoxia-inducible switch that determines peroxisomal fate and links the hypoxic microenvironment to loss of hepatocyte differentiation...Read more

Mitochondria are well known as the energy factories of human cells, but their roles extend well beyond ATP production, with multiple links to other cellular functions continuously being discovered. As can be seen in the subcellular resource of the HPA, the positioning of mitochondria within cells is variable, both between cell types and from cell-to-cell. This arrangement is not random, but rather regulated and highly dynamic. In fact, their proximity and direct interactions with other organelles can regulate cellular processes in these compartments...Read more

In a recent study published in Nature it was discovered that the polyamine spermine acts as a chelator of intracellular iron and thus as a suppressor of ferroptosis. Spermine is a polyamine metabolite that is essential for cellular homeostasis, with known roles ranging from DNA stabilization and RNA processing to protein synthesis and ion channel regulation. Dysregulation of spermine metabolism is implicated in various malignant, neurodegenerative and inflammatory diseases...Read more

In the Episode 82 of of the Proteomics show podcast series "Alt Proteomics" HPA researcher Dr Cecilia Lindskog talks about the importance of proteomics data integration together with the hosts Benjamin Neely and Ben Orsburn...Read more

In the new release version 25.1 of the Human Protein Atlas, a major dataset based on Deep Visual Proteomics has been integrated in the Single cell Resource to provide mass-spectrometry based proteomics at an unprecedented resolution for a large number of cell types and tissues...Read more