The Global Biodata Coalition has selected the Human Protein Atlas (HPA) as the Global Core Biodata Resource (GCBR) of the Week. HPA was appointed GCBR in December 2023 and is one of about 50 resources including Ensembl, Uniprot, GeneOntology, DDBJ, Reactome and STRING...Read more

Dr. Cecilia Lindskog, a research group leader at Uppsala University and director of the Uppsala site of the HPA project, has been awarded the 2024 Erik K. Fernström Foundation's Prize for young, particularly promising researchers...Read more

Female fertility relies on the ovarian follicles that form during fetal development. Some medical treatments, such as chemo- or radiotherapy, are toxic to follicles and therefore ovarian tissue cryopreservation is used as a standard method for fertility preservation. This method is used for both adults and prepubertal individuals, even if its efficiency for tissue collected before puberty is not well documented...Read more

Previously, it was believed that the presence of an oncogenic mutation within a cell was sufficient to drive tumour development. However, it is now understood that tissues may contain cells harbouring oncogenic mutations, but that these cells maintain a normal phenotype until an initiating factor promotes oncogenic transformation (Acha-Sagredo et al, 2021). Changes in the cellular milieu and tissue architecture, such as inflammation or parenchymal density, are thought to alter the behaviour of these cells, affecting the likelihood of oncogenic transformation (Ling et al, 2020; Singh et al, 2019). Nonetheless, the precise mechanisms that underlie cancer promotion, and their association with factors such as smoking or obesity, are not fully understood...Read more

G-protein coupled receptors (GPCRs) are a large family of cell surface receptors important for activating cellular responses. They are activated by many types of signals like light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters and are involved in a wide range of diseases which have made them important drug targets. Receptor activity-modifying proteins (RAMPs) form complexes with the GPCRs and may regulate their cellular trafficking and pharmacology...Read more