News Articles

Altered plasma protein profiles in genetic FTD


In a study published in Molecular Neurodegeneration an international group of scientists including researchers from KTH have used a multiplex plasma profiling assay and a well-described genetic frontotemporal dementia (FTD) cohort collected within the GENFI study to explore potential plasma biomarkers that could reflect the pathology of this disease...Read more

Identification of a potential plasma biomarker for Venous thromboembolism


In a recent publication in Nature communications proteomics profiling was used in an attempt to identify novel biomarkers that are associated with acute Venous thromboembolism (VTE) and linked to disease pathogenesis and risk. A case-control study derived from the VEBIOUS cohort identified the gene CFHR5 as a potentially promising VTE-associated plasma biomarker...Read more

Proteomic profiling of sarcoidosis patients


In a very recent study, published in Respiratory Research, researchers from the Human Protein Atlas and Karolinska Institutet performed protein profiling of broncho-alveolar lavage (BAL)-fluid and serum using an antibody suspension bead array technology with the aim to find proteins associated to sarcoidosis.

Sarcoidosis is a granulomatous systemic inflammatory disease in which more than 90 % of all patients develop pulmonary manifestations. Several gene associations have previously been described, but established and clinically useful biomarkers are still absent...Read more

On childhood asthma and protein profiles in plasma


In a recent publication in European Journal of Allergy and Clinical Immunology, researchers use an affinity proteomics approach to analyze plasma profiles of a 362 proteins in 154 children with persistent or intermittent asthma and controls. To this end, antibody suspension bead arrays developed within the Human Protein Atlas was used.

Asthma is a common chronic childhood disease with many different phenotypes that need to be identified. Asthma affects approximately 300 million people worldwide and is characterized by bronchial hyperresponsiveness and reversible expiratory airflow limitation...Read more