The cell is a multi-scale structure with modular organization across at least four orders of magnitude. Two central approaches for mapping this structure — protein fluorescent imaging and protein biophysical association — each generate extensive datasets, but of distinct qualities and resolutions that are typically treated separately. Here we present a computational framework to build a unified hierarchical map of human cell architecture...Read more

Soon it is time for the summer holiday! But before you can take that well-deserved vacation there are many things that have to be done. Speaking of the need of multitasking, that is what many proteins have to do every day to keep your body up and running...Read more

The centrosome is a non-membranous subcellular structure composed of a mother and daughter centriole. The mother centriole function as the assembly point for the primary cilium, a microtubule-based sensory organelle, which is involved in signal transduction...Read more

SUN2 (Sad1 and UNC84 domain containing 2), found in the nuclear membrane of cells, is an essential protein for many cellular processes. SUN plays a large role in the organization of multi-nucleated muscle cells, and dysregulation of SUN can cause muscular dystrophy among other diseases...Read more

Autophagosomes play a crucial role in recycling, by degrading cellular components and providing building blocks for renewal och cell components. Last year, we published a post about autophagy, which was the subject of the 2016 Nobel Prize in Physiology and Medicine.

We show, for the first time, images of HPA antibodies that co-localize with the autophagosomes. These membrane bound vesicles are involved in degradation of cellular constituents through a process called autophagy. The protein detected is localized to the autophagosomes (green) in SH-SY5Y cells, a human neuroblastoma cell line from neural tissue...Read more