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Discovery of Functional Alternatively Spliced PKM Transcripts in Human Cancers

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Pyruvate kinase muscle type (PKM) is a key enzyme in glycolysis and is a mediator of the Warburg effect in tumors. The association of PKM with survival of cancer patients is controversial. This study investigated the associations of the alternatively spliced transcripts of PKM with cancer patients' survival outcomes and explained the conflicts in previous studies. The article has recently been published in the journal Cancers...Read more