Detection of cancer is a challenging task, especially since many common diffuse symptoms overlap with non-malignant conditions. In an article in Nature Communications it was shown that plasma protein profiling can be used to identify cancer among patients with non-specific symptoms...Read more

The ability to balance the amount of cellular components, remove damaged entities and recycle molecules by controlled degradation is crucial for cellular function and homeostasis. Lysosomes play a central role by acting as a major hub for degrading proteins, polysaccharides and lipids delivered by autophagy and endocytosis. This is mediated by various hydrolases, specifically acting in the acidic environment maintained in the lysosomal lumen. The lysosomal degradation chamber is isolated from the rest of the cell by a lipid bilayer containing numerous membrane proteins, which are coordinating the functions of lysosomes in processes such as cell homeostasis, metabolism, signalling and stress responses. The membrane proteins themselves are protected on the luminal side by glycosylation, which is key to lysosomal integrity...Read more

In this edition of multiplex image of this month, calcyphosine like (gene: CAPSL) is visualized in ciliated cells of the cervix...Read more

2025 was a year of intensified global conflicts, political instability and climate extremes, but also the year when renewable energy became a larger energy source than coal, the first gene therapy for Huntington's disease showed remarkable results, the first malaria treatment for infants was approved by WHO and the green sea turtle bounced back from near extinction. From the HPA perspective it was an interesting and fruitful year from which we will share some of the highlights...Read more