In a recent study published in Nature it was discovered that the polyamine spermine acts as a chelator of intracellular iron and thus as a suppressor of ferroptosis. Spermine is a polyamine metabolite that is essential for cellular homeostasis, with known roles ranging from DNA stabilization and RNA processing to protein synthesis and ion channel regulation. Dysregulation of spermine metabolism is implicated in various malignant, neurodegenerative and inflammatory diseases...Read more

In this episode of Proteins Unfolded Evelina Sjöstedt, head of Single cell analysis at the Human Protein Atlas, joins the hosts PhD students Andrea Villanueva Raisman and Emilio Skarwan to explore the transcriptome, the bridge between our static DNA and active proteins...Read more

In the Episode 82 of of the Proteomics show podcast series "Alt Proteomics" HPA researcher Dr Cecilia Lindskog talks about the importance of proteomics data integration together with the hosts Benjamin Neely and Ben Orsburn...Read more

Glycolysis-associated enzyme pyruvate kinase L/R (gene: PKLR) is here highlighted in specific tubular structures in the kidney using multiplex immunohistochemistry (mIHC/IF)...Read more

In the new release version 25.1 of the Human Protein Atlas, a major dataset based on Deep Visual Proteomics has been integrated in the Single cell Resource to provide mass-spectrometry based proteomics at an unprecedented resolution for a large number of cell types and tissues...Read more