Changes in metabolic pathways are frequently seen in cancer cells, and mutations in certain metabolic genes may even play a direct role in cancer development and progression. One gene for which this is true is the multi-localizing gene fumarate hydratase...Read more

Enolase 1 (ENO1), or alpha enolase, is a glycolytic enzyme with a highly interesting subcellular localization profile. In the subcellular section of the Human Protein Atlas, it is apparent that alpha enolase can be found both in the cytosol, at the plasma membrane and in the nucleus, making it one of thousands of multi-localizing proteins...Read more

Approximately 11% of the human proteins are defined as missing proteins. These proteins lack experimental data on the protein level. In an investigation led by Sjöstedt et al, an integrated omics approach was applied to explore and identify missing proteins...Read more