A recent Molecular Systems Biology study used exploratory spatial proteomics to investigate early changes in high-grade serous ovarian cancer, including precursor lesions in the fallopian tube. In this interview by Gustav Ceder, Dr Fabian Coscia and Dr Mihnea-Paul Dragomir discuss how the team moved from spatial proteomics discovery to tissue-based validation using an Atlas Antibodies / Human Protein Atlas antibody against DHCR7...Read more

Endometriosis is a common gynecological disease that affects 4 to 10% of women worldwide and is characterized by the presence and the development of functional endometrial tissue outside of the uterine cavity...Read more

Approximately 11% of the human proteins are defined as missing proteins. These proteins lack experimental data on the protein level. In an investigation led by Sjöstedt et al, an integrated omics approach was applied to explore and identify missing proteins...Read more

Multiplex proteomics methods enable researchers to identify and characterize the antibodies produced in the human body. Characterization of the auto-antibody repertoire and changes in the targeted antigens in relation to diseased states can provide new venues to understand pathology of diseased states...Read more

The resources produced within the Human Protein Atlas are used by scientists to promote optimization of methods for production of active proteins and development of antibody therapeutics...Read more