Mitochondria are well known as the energy factories of human cells, but their roles extend well beyond ATP production, with multiple links to other cellular functions continuously being discovered. As can be seen in the subcellular resource of the HPA, the positioning of mitochondria within cells is variable, both between cell types and from cell-to-cell. This arrangement is not random, but rather regulated and highly dynamic. In fact, their proximity and direct interactions with other organelles can regulate cellular processes in these compartments...Read more

"Movember" marks the time of the year when men around the world grow their moustaches to raise awareness for men's health issues, such as prostate cancer, the second most common cancer in men and one of the leading causes of death in men worldwide. (Rawla et al, 2019)..Read more

Mitochondria harbors an own genome that renders key proteins involved in production of energy through oxidation of various substrates. Majority of the disorders associated with mitochondrial function are caused by impaired expression of the proteins encoded in the mitochondrial genome. One of these proteins is the translational activator of cytochrome c oxidase 1 (TACO1).

Experimental results reveal that TACO1 is expressed in all tissues within the human body. The protein is detected mainly in the cytoplasm and more precise inside mitochondria. Explore expression and subcellular localization of TACO1 in the Cell Atlas...Read more

This week, it is Mitochondrial Disease Awareness Week. Therefore we would like to take the opportunity to talk about the mitochondrial proteome, the work we do within this field, and you will even get to meet one of our researchers, involved in this work.

The mitochondria are distributed throughout the cytoplasm of the cell, each organelle enclosed by a double membrane, the inner one forming the characteristic folds known as cristae. Mitochondria are essential for producing the cell´s need of ATP through cellular respiration, but have also been shown to participate in many other cellular functions, including apoptosis, calcium storage and cellular signaling...Read more

Welcome back to Image of The Week! We will be periodically highlighting an organelle in the coming image of the week posts, written by members of the Subcellular Human Protein Atlas project. This week we kick things off with a post by HPA_Illuminator, and what better way to start than with the mitochondria, the (true) powerhouse of the cell!!!

Mitochondria are found in almost all human cells, in varying numbers. They are known as the powerhouse of the cell as they are responsible for producing the majority of the energy in your body (in the form of ATP, adenosine triphosphate)...Read more