Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disorder associated with high morbidity and early mortality. Rapidly progressive cell death of upper and lower motor neurons in the brain as well as in the spinal cord leads to loss of voluntary muscle control. Within a few years of diagnosis, patients lose the ability to move, speak, eat and breath without mechanical support. There is no cure for ALS, with current treatments merely aiming at slowing disease progression and improving symptoms...Read more

In a study published in Journal of Proteome Research, >180 proteins have been spatially mapped to specific subcellular compartments in cells with motile cilia using multiplex immunohistochemistry. The high-resolution data is available in the HPA Tissue resource, and aids in further functional mapping of proteins with limited evidence...Read more