Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disorder associated with high morbidity and early mortality. Rapidly progressive cell death of upper and lower motor neurons in the brain as well as in the spinal cord leads to loss of voluntary muscle control. Within a few years of diagnosis, patients lose the ability to move, speak, eat and breath without mechanical support. There is no cure for ALS, with current treatments merely aiming at slowing disease progression and improving symptoms...Read more

In the latest episode of the new Proteomics show podcast series, "All the parts", neuroscientist at Karolinska Institute and HPA researcher Jan Mulder talks about many different aspects of the brain and brain research together with the hosts Benjamin Neely and Ben Orsburn...Read more

A publication on characterization of tau pathology in the locus coeruleus in the human brain using three-dimensional imaging was recently selected as recipient of a 2023 Publication of the Year Award by the Alzheimer's Association ISTAART. The study was published in Acta Neuropathologica and involved, among others, research groups from Karolinska Institutet and Science for Life Laboratory (SciLifeLab) in Stockholm, Sweden...Read more

Multiplex proteomics methods enable researchers to identify and characterize the antibodies produced in the human body. Characterization of the auto-antibody repertoire and changes in the targeted antigens in relation to diseased states can provide new venues to understand pathology of diseased states...Read more